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Unfolded protein responses page Proteins are assessed in the Endoplasmic Reticulum for proper folding before released to the secretory pathways. This measure is to prevent misfolded proteins from entering the extracellular environment where they can be disruptive. Misfolded proteins can take two secretory pathways from the ER; the RESET pathway and ERAD pathway. RESET pathway is amplified when there is ER stress, majority of misfolded proteins will take this pathway when ER stress is present. (take diagram of RESET pathway off of powerpoint).

Prasanna Satpute-Krishnan, ER stress-induced clearance of misfolded GPI-Anchored Proteins via the Secretory Pathway