User:Jeff0815

M2-PK Test

The M2-PK Test is a non-invasive screening method for the early detection of colorectal cancers as well as Polyps who are known to be the precursors of colorectal cancers. The M2-PK Test which is used for stool analysis is available either as fully quantitative ELISA Test or as a rapid test that can be performed by any general practitioner without the need of a laboratory or any additional equipment. The enzyme biomarker M2-PK has been identified as a key enzyme in colorectal cancers and polyps. The detection of M2-PK does not depend on blood in the stool and is specifically related on changes in the tumor metabolism. False positive results by unspecific blood sources in the bowel are excluded and the test is able to detect both bleeding as well as non-bleeding colorectal cancers and polyps. The M2-PK Test is able to detect 80.3 % of colorectal cancers whereas only 4. 8 % of the results are false positive. Therefore this approach makes an outstanding contribution to screening of colorectal cancers in asymptomatic patients since the detection of FOBT in comparison is dependend on a blood source that may not be related to colorectal cancers or polyps. An elevated concentration of M2-PK in the stool should always be clarified by undergoing colonoscopy.