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Leukocyte Distribution
Leukocyte cells are an important composition to the human body. It’s a necessity in order for the body to fight off foreign pathogens and diseases. They are also known as white blood cells and they are what helps us defend and protect our body in our day to day lives. These cells are all over the body and in the bloodstream, this is called the lymphatic system. Where the blood is made up of red blood cells, plasma, palettes and white blood cells. The physical aspects of leukocyte cell is this white layer of blood distinguished between the plasma and the red blood cells. In order to find this white layer a portion blood extracted from the human body and centrifuged (or vortexed). This process is what nucleates the blood sample and separates the white blood cells, plasma and red blood cells. As they have different appearances they also have different densities which cause them to layer on top of each other.

Leukocyte cells also have many types to them in order to defend against. The distribution of these types are also different depending on the organs and bloodstream and how the blood is carried out.

When a foreign particle or pathogen enters and by passes all the other defensives, and into the bloodstream it sets off an alarm that alerts the immunity system activating certain leukocytic cells and aids in remove said foreign particle or pathogen. These cells can also be labelled as macrophages, which allows the body to go through phagocytosis. Macrophages include basophils, dendritic cells or neutrophils, which aid in defending against pathogens. At times, it comes to a point where this line of defense sometimes fails and relies on the more sophisticated cells and turns to t-cells and b-cells and there are various types of these cells within the body too and different distribution in different areas. These are like the special security force within the bloodstream that uses the interactions with pathogens and past experiences in order to fend off and kill the foreign particles.

These leukocytic cells also may help scientist in the future as a role to develop and treat cancer. Certain t-cells may provide therapy to treat multiple cancers and have been studied in previous clinical trials that there may be potential treatments to leukemia and lymphoma.

Leukocytes
The general knowledge for leukocytes are white blood cells that act as a immunity system in the body but it is much more than that. It is heavily studied on what there roles are in the body whether it’s the metabolism or growth and ideas of how the leukocytes prevent and protect further developments of pathogens.

B-cells and T-cells
The derivation of of t-cells and b-cells are the main cell components to the adaptive immune system and their response. The t-cells derive off the thymus cells and the b-cells derive off the bone marrow or bursa-derived cells. The response of b-cells are responsible for antibodies related production as each foreign pathogen may have a cell wall that is unique in its composition and needs to be broken down by an antibody. T-cells respond in mostly cell mediated immunity where the cells are used to engulf or destroy the foreign cells completely. Additionally, By making shaped proteins that looks like Ys the b-cells fight off pathogens by creating antibodies that help break down the cell wall of the pathogen. This marks the the invading cell so that the macrophages which includes the white blood cells to come and destroy it.

There are two armies of cells that make up the immune system in the bloodstream, these are the innate immunity and the acquired immunity. The innate immunity is what’s built into our genes and are cells that are part of the first line of defense, to fight infection or to defend the body against any viruses or bacteria. Acquired immunity also known as adaptive immunity is like a gift which uses elements of the t-cells and b-cells mentioned above to defend against anything that slips through the innate immunity. But there is a downside to these cells they take time to develop and adapt so if a pathogen slips by faster it may not have enough time to respond. These cells learn from their previous experiences and evolve in their behaviours, this then allows them to have a longer life span that innate immune cells. The adaptive immunity always remembers their encounter with foreign cells and allows them to create cells that break down the composition of the foreign cells, so when encountered again they are able to destroy and defend the body when it comes to it. This is the prime example of how vaccines work by introducing a small dormant strain of the pathogen the body adapts and remembers and creates a method of fending of the pathogen when encountered actively.

Now all b-cells and t-cells are lymphocytes, they are made in the bone marrow like the red blood cells. The b-cells tend to stay in the bone marrow longer than the t-cells in order for them to mature, while the t-cells need to travel to the thymus gland and mature there.

White Blood Cell Composition
White blood cells are known as leukocytes(clearly mentioned above). They can be categorised into granulocytes and agranulocytes. These are the macrophages that the granulocytes consist of neutrophils, eosinophils and basophils. They have cytoplasms in the organelles, as they appeared as if coloured granules through a light microscope.

Distribution
Leukocytic cells or lymphocytic cells are immune cells which are important in humoral and cellular and have become fundamental in research. Studying their distribution can allow us to see how best the immunity works. THese cells represent 20-40% of white blood cells, this includes the t-cells and the b-cells. In the peripheral blood about 15-25% of the blood are b-cells and the 40-75% are t-cells.

An important thing to note is that these cell distribution aren't always accurate and the granulocytes using circulation can increase and decrease through different mechanics.

Most instances of neutrophilia are secondary to a pathologic process outside the marrow. It can occur in infectious diseases, especially acute bacterial infections; neoplasia, either affecting the myeloid system (chronic myelogenous leukemia and other myeloproliferative disorders) or secondary to a solid tumor (paraneoplastic syndrome); inflammation secondary to tissue necrosis, metabolic and collagen diseases, hypersensitivity reactions; hemorrhage; hemolysis; and stress.