User:Jenil21/CCR4-Not

Lead
Ccr4–Not complex plays an important role in mRNA decay and protein quality control in the cytoplasm. Ccr4-Not possesses exonuclease activity that shortens the poly(A) tail found at the 3' end of almost every eukaryotic mRNA. In yeast the complex has nine core subunits, comprising Ccr4 (carbon catabolite repression), Caf proteins (Ccr4 associated factor) (Caf1, Caf40, Caf130) and Not proteins (Not1, Not2, Not3, Not4, and Not5).

Article body
In mammalian cell, it has a function in the regulation of the cell cycle, chromatin modification, activation and inhibition of transcription initiation, control of transcription elongation, RNA export, nuclear RNA surveillance, and DNA damage repair in nucleus.