User:Jenstrommen/sandbox

Summary
Neuroblastoma protein family 19 (NBPF19) is a gene that produces an uncharacterized protein of interest and unknown function. This product contains a high number of DUF1220 repeats, which have been implicated in the evolution of humans' large brain size as well as increasing severity of autism spectrum disorder symptoms in diagnosed individuals (cite paper 2014). It was discovered in human hippocampal tissue during an unpublished human cDNA sequencing project on splicing variants conducted by Wakamatsu et al in YEAR, the only written record of it.

Gene and mRNA
The gene is located on Chromosome 1 at the locus 1q21, and may have multiple start sites of transcription between the 140 and 149 millionth base pairs [BLAT citation]. It produces a primary transcript mRNA FLJ61634[NCBI citation] which is 4085 base pairs long and encodes at least one unnamed protein of unknown function[NCBI citation]. According to RefSeq, nbpf19 can produce at least 4 mRNA transcript variants[RefSeq citation].

Protein
The gene nbpf19 produces the protein of unknown function characterized by van Roy & Staes[citation] and, later, Wakamatsu et. al[citation].

(alternate protein?) (3749-bp) of the protein may exist.[citation]

Homology and Evolution
The most closely related paralogs in primates are the other members of the neuroblastoma breakpoint family in Homo sapiens and Gorilla gorilla gorilla. There may be orthologous genes in other species, one possibility being Danio rerio, though the similarity is weak (BLAST).