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Preliminary Outline for Ribonucleotide article
Lead Section Discovery of ribonucleotide Structure Function Images
 * Definition of ribonucleotide
 * General scope and description
 * History of ribonucleotide
 * Explain the 4 different units of ribonucleotide
 * Distinction between nucleotide and ribonucleotide
 * Differentiate between purines and pyrimidines
 * Ribonucleotide as precursors of deoxyribonucleotides
 * Biosynthesis of purine and pyrimidine with a focus on the enzymes involved
 * Roles ribonucleotide play in RNA and how they are involved in transcription
 * Reduction of ribonucleotide
 * http://en.wikipedia.org/wiki/File:AMP_structure.svg#file
 * http://en.wikipedia.org/wiki/File:GMP_chemical_structure.png
 * http://en.wikipedia.org/wiki/File:Uridinmonophosphat_protoniert.svg
 * http://en.wikipedia.org/wiki/File:CMP_chemical_structure.png

References for Ribonucleotide Article
Ribonucleotide reductase genes in Escherichia coli
 * Ribonucleotide reductase (RNR) is an essential enzyme for all living organisms since is the responsible for the last step in the synthesis of the four deoxyribonucleotides (dNTPs) necessary for DNA replication and repair.

Molecular Biology of the Gene

Ribonucleotide reduction
 * Ribonucleotide reductase provides deoxynucleotides for nuclear and mitochondrial (mt) DNA replication and repair.

Principles of Biochemistry
 * Gives general information about structures of ribonucleotides
 * Provides information on how ribonucleotides differ from deoxyribonucleotides
 * Ribonucleotides are the Precursors of Deoxyribonucleotides-Deoxyribonucleotides are derived from the corresponding ribonucleotides by direct reduction at the 2'-deoxy derivative. Reaction is unusual as reduction occurs are a nonactivated carbon. The reaction is catalyzed by ribonucleotide reductase. In E.coli, its substrates are ribonucleoside diphosphates. Reduction of the D-ribose portion of a ribonucleoside diphosphate to 2'-deoxy-D-ribose requires a pair of hydrogen atoms, which are donated by NADPH via an intermediate hydrogen-carrying protein, thioredoxin.

Ribonucleotide discrimination
 * DNA polymerases select against ribonucleotides which are present at much higher levels compared with deoxyribonucleotides.

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Summary of Characteristics of Target Article
GA Article
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Unit 5: PubMed Assignment
The herbicide atrazine is one of the most commonly applied pesticides in the world. As a result, atrazine is the most commonly detected pesticide contaminant of ground, surface, and drinking water. Atrazine is also a potent endocrine disruptor that is active at low, ecologically relevant concentrations It demasculinizes and feminizes the gonads of male vertebrates by producing testicular lesions associated with reduced germ cell numbers in teleost fish, amphibians, reptiles, and mammals, and induces partial and/or complete feminization in fish, amphibians, and reptiles. Atrazine affects vertebrates through various mechanisms, but the mechanism most consistent with the effects observed on amphibian reproduction is the induction of aromatase, which is consistent with the natural sex differentiation process in X. laevis (African clawed frog).