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Unconventional myosin-VI, is a protein that in humans is coded for by MYO6.

Contents

 * 1Function
 * 2Interactions
 * 3References
 * 4Further reading
 * 5External links

Function and Structure[edit]
Unconventional myosin-VI is a molecular motor involved in intracellular vesicle and organelle transport. Myosin-VI is unique because it travels in the opposite direction of other myosin, towards the negative end of actin filaments. Myosin-VI follows the same structure as other myosin but with two unique "inserts" allowing for its diversified properties. One insert is called the "reverse gear" and is responsible for its movement towards the negative end of actin filaments. The reverse gear is located on the neck region of the myosin and acts as a reorienting device for the lever arm to move backwards after myosin movement. The second insert assists in regulating ATP enzyme activity located in the motor head domain.

There are 3 amino acid binding sites essential for myosin-VI's interactions, Arg-Arg-Leu and Trp-Trp-Tyr in the tail region and Met-Ile-Sec in the helix. The Arg-Arg-Leu amino acid segment (abbreviated RRL) takes part in ubiquitin interactions while Trp-Trp-Tyr (abbreviated WWY) assists in interactions with DAB2. Myosin-VI's Met-Ile-Sec bonding interactions are limited to the myosin-VI long isoform but interact with clathrin in endocytosis.

Myosin-VI long isoform is formed by the inclusion of exon 31, adding an addition alpha-helix, restriction RRL interactions. Myosin-VI long struggles to interact with ubiquitin chains and GIPC1 due to this structural formation, however, increases attractivity to clathrin.

Interactions[edit]
MYO6 has been shown to interact with GIPC1, DAB2., ubiquitin, and clathrin

References[edit]

 * 1) ^ Jump up to:a b c GRCh38: Ensembl release 89: ENSG00000196586 - Ensembl, May 2017
 * 2) ^ Jump up to:a b c GRCm38: Ensembl release 89: ENSMUSG00000033577 - Ensembl, May 2017
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 * 13) Zakrzewski, P., Lenartowska, M. & Buss, F. Diverse functions of myosin VI in spermiogenesis. Histochem Cell Biol 155, 323–340 (2021). https://doi.org/10.1007/s00418-020-01954-x