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Unit 7 Assignment - (Outline, References, Images, Suggested Improvements)

 * Group Page Talk link: Group_84D (talk)

Outline for Article: Inverted Repeat --- (talk page for Inverted Repeat article)

 * 1) Lead paragraph (brief introduction)
 * 2) Definition & Examples
 * 3) cartoon to explain - Jim Perry has an idea for this - to be developed in future weeks
 * 4) Examples of Inverted Repeats
 * 5) Other types of repeats
 * 6) direct repeats vs. inverted repeats
 * 7) palindromes vs. inverted repeats
 * 8) Biological Features & Functionality
 * 9) Origin of Inverted Repeats - How they are introduced.
 * 10) Conditions that favor synthesis of Inverted Repeats.
 * 11) Most common biological functions using Inverted Repeats.
 * 12) Regions where presence is obligatory.
 * 13) Location of inverted repeats in the genome - how, why and where
 * 14) Inverted repeats common in different organisms
 * 15) Databases of Inverted Repeats (with External Links as appropriate)
 * 16) References

Information about the References

 * Inverted Repeats and DNA replication. 1996 review article.  Might be good (or might be too old?)


 * RNA related. Is CRISPR a potential category? CRISPR = Clustered Regularly Interspaced Short Palindromic Repeats


 * palindrome-mediated translocations are localized at the center of palindromic AT-rich repeats (PATRRs)


 * DNA inverted repeats in the genome. Might be a special category?


 * Folded DNA - Hairpins


 * Inverted repeats in the male-specific region of the human chromosome Y(MSY)


 * Instability of palindromes by formation of a hairpin or cruciform structure and the resultant chromosomal deletion or translocation.


 * Holliday-junction resolution in homologous recombination and coding joint formation in rearrangement of antigen-receptor genes.


 * Hypertensive crises caused by inverted left atrial appendage.


 * Families of inverted repeat fold transporters.


 * Size and distribution of inverted repeats in D. melanogaster DNA.


 * Transient blindness and transurethral resection.


 * Inverted sequences among families of repetition frequencies.


 * Faulty application fork maintenance pathways at nonallelic repeats and cancer and genomic disorders and speciation.


 * The properties of inverted repeat sequences in wheat nuclear DNA.


 * Invereted repeats in spinach, corn and lettuce.


 * Inverted repeats in MDg3 of Drosophila melanogaster.

References:

Possible Images
We will need to get permission before using these unless already under the proper license:

Hairpin Image: http://course1.winona.edu/sberg/ILLUST/hairpin.JPG

Open Access Article: http://www.biomedcentral.com/1471-2164/7/73/
 * See Figure 3 in this article for a good example of an inverted repeat
 * Here is the link to the photo: http://www.biomedcentral.com/1471-2164/7/73/figure/F3

Palidrome and mirror repeats: http://www.siumed.edu/~bbartholomew/images/Lehninger/img035.gif

Examples of inverted repeats: http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/R/RecognitionHelix.gif

Suggested Improvements: These are listed on the talk page for the article

 * LINK: Article talk page (for the Inverted Repeat article)