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Article Considerations

Initiation Factor

Crandall Syndrome

Cellular Adaptation

Protein unc-119

Initiation Factor

Initiation factors are used in both transcription and translation. They are proteins that do not include RNA polymerase. Other than a few differences, protein synthesis is generally the same in both bacteria and eukaryotes

Initiation factors can interact with repressors to slow down or prevent translation or they can interact with activators to help them start  or increase the rate of translation. In bacteria they are simply called Ifs (i.e.., IF1, IF2, & IF3) and in eukaryotes they are known as eIFs (i.e.., eIF1, eIF2, eIF3). In eukaryotic transcription these are also called the general transcription factors, or σ factors

Initiation factors are principally part of one of the most complex stages in protein synthesis, called the initiation process. These factors are important in ensuring the processes get carried out correctly by safeguarding the interactions among mRNA, tRNA, and mRNA. In eukaryotes, the initiation factors assist in the assembly of a 40S ribosomal subunit, which interacts with tRNA and forms a 48S initiation complex.

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