User:Jkxgao/Johnson Gao

Johnson K. Gao, used name: Kuixiong Gao, or, Gao Kui-Xiong (高魁雄) as expressed in the traditional Chinese name-calling, - a Chinese-born US citizen born in May 3, 1937, Shanghai, China, is a multi-talented “renaissance” man. He is a scientist (with many research articles and scientific books published) as well as an artist (with variety art pieces published). He is also a music composer, who has five electronic music CDs published.

Johnson Gao’s scientific achievements are outstanding. He had used the name Kuixiong Gao for most of his scientific publications. That name had been listed in the “American men & women of Science” since 1992. His scientific endeavor covers broad areas including induction of lens by presumptive retina in tadpoles in frog, muscle biochemistry of rabbit and bull frog, molecular structure of neuro-muscular junction, liver enzymes in relation to diabetes, mechanism of herbal contraceptives and hormone metabolism, membrane bio-genesis, the rule of growth factor in embryo development, etc. He had published more than forty scientific research articles and six books. His research papers had been requested by more than two hundred laboratories all over the world. When he was an experimental embryologist, he created many three-eyed tadpoles in 1960. As a microscopist and microphotographer, he invented the silanated water-soluble amino plastic for electron microscopy to observe lipoprotein molecules in membrane bio-genesis (Acta Biologiae Experimentals Sinica, 16,325-337, 1983), also (ibid, 18,13-23, 1985). He also invented a unique polyethylene glycol section method – which is a breakthrough against the century-old paraffin section method. He is the editor of the book: “Polyethylene Glycol as an Embedment for Microscopy and Histochemistry” (edited by Kuixiong Gao and published by CRC Press in 1993). PEG section method can improve the quality of immuno-histochemistry. The new method offers a better way for the environmental protection, since toxic solvents normally used in paraffin section method can be avoided in his PEG section procedures. When he was a biochemist, he established a gas liquid chromatographic method that can detect prostaglandins at sub nanogram (one millionth of a gram) level. That method was published in 1979. It was used in a research project to study the mechanism of herbal medicine. He invented the solid-core liposome for drug delivery at the University of Tennessee, in 1985. Based on his method, the University of Tennessee had applied a patent for that technique. He was the first person to make the colloidal gold encapsulated solid core liposomes and use them as drug carriers (Biochm. Biophys. Acta, 897,377-383, 1987). That method was actually a gold nano technology before the terminology of nanotech was popularly known today. During late 1980s and early 1990s he had contributed something special in neuroscience and diabetes research. He had developed a complicated procedure by using epipolarization microscopy and immunogold silver staining to detect enzymes at sub-cellular level. He invented a new method using polyethylene glycol as a water soluble embedment for preparation of microscopic slides of tissue sections in 1990 (J. Histochem. Cytochem., 39,537-540). That method, using PEG and water to replace wax and organic solvents, can be used as an alternative method to replace the century-old paraffin section method for better immunostaining and environmental protection. He was one of the frontiersmen using immunogold silver stain-epipolarization microscopic detection and image processing method that can bridge the gap between microscopy and electron microscopy for macro molecule localization within cells (J. Histochem. Cytochem., 42,1651-1653, 1994) and (JMSA, 1:4,151-161, 1995).

As an artist, he has a nick name “Gao Gao” in the recent years. He published his drawing “A Lonely Hut” (“Mao Wu”) in a kid’s journal (“Xiao Peng You”) when he was thirteen years of age. One of his childhood paintings was recovered/re-mounted from a half-century old rice paper painting that he had painted when he was only twelve years of age, and he added a Chinese poem onto it few years ago. It was a bird. See inserted image below.

Then, he learnt the basic painting skill from his high school art teacher Mr. Zhang Bei-Lu, who was skilled in oil painting. In the late 1950s when he was at the Nanjing University, Gao Gao became a student of Prof. Li Jian-Chen, who was the top famous artist in watercolor painting and the author of the book: “Shuicaihua Jifa” (“Skills in Watercolor Paintings”). Prof. Li lived over a hundred years and he was known as the father of watercolor in China. At the same period of time, Gao Gao studied other drawing techniques through a thick book: “Drawing with Pen and Ink Brush”. He began to publish his arts, chiefly birds and animals, as illustrations for biological books written by his university professors. Gao Gao practiced his first oil painting along 1960. It was a portrait of his college classmate, Mr. William Lu (also called Lu Wei-Cheng or Fang Mian-Shui), who is a Canadian biologist/artist born in Hongzhou, China. Gao Gao also learnt the skill of Chinese ink-brush quick-painting over rice paper to paint swimming shrimps vividly. That was a unique style created by the great Chinese art master Mr. Qi Bei-Shi. One of Gao Gao’s ink-brush paintings of swimming shrimp was published at the Phoenix journal of the University of Tennessee at Knoxville in the fall issue of 1990.

Eight shrimps. Chinese ink brush on rice paper 10x7” painted by Gao Gao in 1988. See http://www.scribd.com/doc/13788/An-album-of-Gao-Gao-Gallery-

Others of similar art had been collected by some important persons, including one former vice-president. A lithography reproduction of “Monterey Bay“, which was jointly painted with his son Raymond Gao in 1999 (oil on canvas), had been collected by the former First Lady of California and the former President of Beijing University. Gao Gao developed his oil painting style by absorbing the essence from great art pieces of all ages in those worldwide famous palaces and museums. He made many global trips, including six times to Europe. He had visited many palaces, such that Louvre, Versailles, Fountain Blue, and others in Vienna, Madrid, Venice, Rome, Innsbruck, Geneva, Prague, Buda Pest, the castle of fantasy – Neuschwanstein in German, and various castles in England, Scotland, Germany and Belgium. He also visited St. Petersburg and Moscow in Russia. All of those experiences had broadened his view and increased his ability in arts appreciation. Besides, he also visited Hawaii, Caribbean islands, Australia and New Zealand, the Great Wall and the Forbidden City in China, palace in Thailand, etc. All of those experiences helped him tremendously in his artistic creation. His serial paintings entitled “Seas of the World” were based on those travels. Basically, Gao Gao’s paintings belong to the realistic style, mingled with some imagination, such that the “Sunset at Monterey Bay” and “Kiss in the Moon”, that he had jointly painted with his son Raymond Gao. Refer to a web site below.

https://finerworks.com/mgallery/artists.asp?U_ID=gaogao

Possibly, it was Gao Gao, who produced the world’s first-color electron microphotograph in 1983, which can show 70 Å lipoprotein molecules at a magnification x1,100,000. See the image below (Bar = 1,000 Å). It is a NanoArt piece produced far earlier than the terminology of NanoArt was created.

At such a magnification a rape seed can be enlarged to the size of a stadium. His artistic training had helped him a lot in computerized image processing of his research data.

One of his microphotographs had won the immunohistochemistry photo contest in 1996 held by Sigma Chemical Company. Another pseudo-color image processed photo was selected as a cover of MSA journal: 1995 JMSA Vol.1 No. 3 front cover. Finally, during the last six years of 20th century, he was attracted by a difficult problem in economy, i.e. whether the stock price is predictable? After painstaking research he finally proposed/invented the Gao’s Equation (alternatively known as the Midas Equation) in 2000. That equation has four terms: $n+x = n$d + $x + n$v. The term at the left side of equation $n+x denotes the stock price under prediction at the time unit n+x, which could be the next week, or, the next day, or, even the next hour, etc. That equation is based on the dynamic balance theory of moving average. He wrote a unique book: “Prediction of Stock with Gao’s Equation” that can be found at a web site –

“Prediction of Stocks with Gao’s Equation”, http://www.amazon.com/Prediction-Stocks-Gaos-Equation-Johnson/dp/B0025US4HY/ref=sr_1_2?ie=UTF8&qid=1248323034&sr=8-2 or,

http://www.amazon.com/Prediction-Stocks-Gaos-Equation-Johnson/dp/1411615751/ref=sr_1_1?ie=UTF8&qid=1248323034&sr=8-1

or, one may search the book title or author’s name through Amazon.com. That equation had been evaluated by himself to be the most important contribution by him at the turning of the century. Gao’s Equation looks as simple as the Einstein’s energy equation E = MC2 in physics. It might be a “gold key” to open a treasury and could be very important to investors.

Besides, he invented a Chinese Pinyin shorthand method. A bilingual book about that method was published at http://www.amazon.com/Pinyin-Shorthand-Bilingual-Handbook-B/dp/B002ACSRLK/ref=sr_1_2?ie=UTF8&qid=1248323208&sr=8-2

An album of 16 pieces of poems and a thesis on an international language called as Singlish at lulu dot com

An abstract in Chinese is attached.

简历 (Abstract in Chinese) 高魁雄博士是一位美籍华人，他出生于中国上海，分别于苏州，上海，南京受幼儿教育，中等教育和高等教育. 1962年起他于中国科学院上海分院攻读免疫胚胎博士研究生. 后来，他因为在中科院领导研究与生命起源和个体发育相关的细胞膜生物发生课题中，创造性地建立了水溶性电子显微镜包埋技术和电子计算机图像处理，早在1983年就成功地做出了世界上第一帧彩色电子显微镜照片，并观察到纳米级的脂蛋白分子在生物膜形成中的作用，于1984年破例地被聘为美国田纳西大学的研究教授. 当他完成了一项能申请专利权的纳米金富集的藻糖~明胶微球作为万能的药物载体之后（此时纳米技术的名字尚未出现)，他又到北卡教堂山州立大学及辛辛那堤医学院做神经传递的分子基础研究和肝脏中糖代谢酶的亚显微细胞内定位等工作. 后者是在美国电子显微镜协会主席Cardell，R.实验室中进行，志在阐述人们知之甚少的肝脏与糖尿病的关系. 并有新的发现. 他是一个具有文艺复兴奇传人物色彩的学者. 他集科学，美术，音乐于一身. 人们很难相信，他一个人既是几十篇科学论文及五本以上科学书籍的作者，编者或合编者，他又有图册，语言专论，拼音速记，音乐光碟，财经专论，乐谱丛集等方面的出版活动. 他的与众不同的诸多爱好及勤学苦练作风，和那种艰苦创造，坚持不懈，百折不挠的精神是造就他成功的因素. 1992年起他的名字 Kuixiong Gao 被列入美国科学家名人录 (American men & women of Science) . 他具有代表性的工作和著作有“探索衰老”（1983年人民卫生出版社）， “肿瘤的免疫治疗”，“Polyethylene Glycol as an Embedment for Microscopy and Histochemistry”，（1993，CRC Press or Amazong.com）, “An Album of Gao Gao Gallery”, http://www.scribd.com/doc/13788/An-album-of-Gao-Gao-Gallery- (That has been viewed by over 130,000 viewers already), “Prediction of Stocks with Gao’s Equation”,

“Pinyin Shorthand”,

以及五张音乐光碟. 他尚有近百篇专题论述，艺术作品，MTV等发布在他的个人网站如下：

(It takes one minute to open due to there are many stuffs in it.) https://finerworks.com/mgallery/artists.asp?U_ID=gaogao http://www.scribd.com/luluext http://www.youtube.com/raygao2000