User:Jlowe24/sandbox

Amyloidosis

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Practice Editing Here (Nov 23rd in-class Wiki session work)

 * This is a place to practice clicking the "edit" button and practice adding references (via the citation button).

Assignment # 3 - Amyloidosis

 * Proposed Changes:
 * Original “The three most common forms of amyloidosis are AL, AA, and ATTR amyloidoses. The median age at diagnosis is 64.[8]  In the western hemisphere, AL is the most prevalent, comprising 90% of cases.[14] In the United States it is estimated that there are 1,275 to 3,200 new cases of AL amyloidoses a year.[7]
 * Changes: “Amyloidosis has a combined estimated prevalence of 30 per 100,000 persons with the three most common forms being AL, ATTR, and AA. The median age at diagnosis is 64. [8]  AL has the highest incidence at approximately 12 cases per million persons per year and an estimated prevalence of 30,000 to 45,000 cases in the US and European Union.”

Next, I changed the two sentences about AL amyloidosis. The first sentence’s statistic regarding “90% of cases” was unfounded in the cited source. Furthermore, they provided an outdated statistic/source from 1997 for the incidence in the second sentence. I replaced these two sentences with a sentence that provided the prevalence and incidence from reputable sources updated within the past 3 years. The information for this sentence change comes from JAMA and Current Medical Research and Opinion. Lin, H. M., Gao, X., Cooke, C. E., Berg, D., Labotka, R., Faller, D. V., Seal, B., & Hari, P. (2017). Disease burden of systemic light-chain amyloidosis: a systematic literature review. Current medical research and opinion, 33(6), 1017–1031. https://doi.org/10.1080/03007995.2017.1297930 Gertz, M. A., & Dispenzieri, A. (2020). Systemic Amyloidosis Recognition, Prognosis, and Therapy: A Systematic Review. JAMA, 324(1), 79–89. https://doi.org/10.1001/jama.2020.5493
 * Rationale for proposed change: I changed the first sentence to include the combined prevalence of all types of amyloidosis. This is a good statistic to provide as it gives the reader an idea of how rare amyloidosis is. Also, I rearranged the order of the last two types of amyloidosis and placed ATTR before AA. This is important because it organizes the types of amyloidosis from most to least common and reflects the current understanding that AA has become rarer than the first two types due to advancements in treating chronic infectious diseases. The information for both changes come from two review articles published within the past 3 years from JAMA and Current Medical Research and Opinion, two highly reputable journals.
 * Area of controversy: An area of controversy is that there is consensus that amyloidosis is vastly underdiagnosed due to vague symptoms and lack of awareness and familiarity of the diseases by physicians. Hospital and clinic-based diagnoses provide lower estimates of incidence compared to the estimated prevalence from death certificates. Thus, the incidence and prevalence statistics may not have high precision. However, given that amyloidosis is a rare group of diseases it is understandable that there are fewer high-quality studies conducted and thus lower precision in the statistics presented.
 * Critique of source: Both authors disclosed many conflicts of interest. Dr. Gertz received personal fees, served on data and safety monitoring boards, received royalties, and most concerning, received grant funding from the Amyloidosis Foundation and the Macroglobulinemia Foundation. Dr. Dispenzieri received grants and personal fees from various organizations as well. These conflicts of interest may have biased many steps in conducting the review, such as inclusion criteria of studies, statistical analyses, and conclusions.

What to post on the Wikipedia article talk page?

 * This will also be covered on Nov 23rd in class. Your group should use the below template to share an outline of your proposed improvements (including your new wording and citations). Article talk pages are not places to share your assignment answers. The Wikipedia community will be more interested in viewing your exact article improvement suggestions including where you plan to improve the article (which section), what wording you suggest, and the exact citation (Note: all citations must meet WP:MEDRS)
 * You will not be able to paste citations directly from your sandbox to talk pages (unless you are interested in editing/learning Wiki-code in the "source editing" mode). We suggest re-adding your citations on the talk page manually (using the cite button and populating the citation by pasting in the DOI, website, or PMID). You will have to repeat this process yet again when you edit the actual article live.
 * Talk Page Template: CARL Medical Editing Initiative/Fall 2020/Talk Page Template