User:Jn1012/sandbox

The absence of POT1 in mouse embryonic fibroblasts and chicken cells leads to a detrimental DNA damage response on telomeres resulting in telomere dysfunction-induced foci (TIFs). POT1 is required for telomere protection because it allows for telomere inhibition of DNA damage response factors. The protein also serves a role in the regulation of telomerase activity. In vitro experiments utilizing human POT1 have shown that reduction in POT1 levels result in the elongation of telomeres.