User:Jocedye/Endocrine disruptor

Overlooking the article, overall it seems well formed, but looking through some of the sources they appear to be rather dated, with one going back to 2002. While the data may echo the same results now, it may be useful to find more recent contributions to the topic. Additionally, the lead banner of this article mentions that more medical sources and uses too many primary sources, which could be a good start to editing this article, by backing up the claims made by the article with secondary sources. Also, one might be able to add to/update the section of known endocrine disruptors. 23:59, 5 February 2023 (UTC)LE4rSt0966 (talk)

In the first paragraph, there is a quote that is pretty long. I think that more sources could be used to instead form a better description of the overview instead of one long quote containing a lot of specific information. In the introductory section, I think more could be said about what endocrine disruptors actually are for readers who may not already have a scientific background and understanding. Then, in a new article section, the history and social significance of them should be discussed. I think talking about the groups who are opposed to them in the introduction is not the best structure for those who are not well informed. Mgattar (talk) 03:31, 30 January 2023 (UTC)

In the Introduction paragraph, I noticed several pieces of language that could be edited to reflect a more neutral stance on endocrine disrupters. For example, using words like "derailed" and "actually harm humans" could be reworded. Many of the sources seem to be from the 1990's, and may be dated as a result. In addition to the other types of endocrine disruptors, I would like to add an additional example: Triclosan (used in anti-bacterial soaps and Colgate Total toothpaste). This may be even more of interest following the outbreak of COVID-19, where anti-bacterial soap use grew exponentially. 05:14, 13 February 2023 (UTC)

The article seem pretty good but need to work on references because in many parts, it ask for medical references or rely to much on primary research. Remember these informations presented to the public and should be more clear and easy to understand not too much scientific terms using.

Article body
Environment and Human Body Cleanup

Although some pollutants like bisphenol A (BPA) are preferentially eliminated from the human body through sweat, recent scientific advances have been made to increase the rate of elimination of pollutants from the human body. For example, BPA removal techniques have been proposed that use enzymes such as laccase and peroxidase enzyme to degrade BPA into less harmful compounds. Another technique for BPA removal is the use of highly reactive radicals for degradation. 1947143432C (talk) 02:59, 27 February 2023 (UTC)

The second step toward lowering human body burden is awareness of and potentially labeling foods that are likely to contain high amounts of pollutants. This strategy has worked in the past—pregnant and nursing women are cautioned against eating seafood that is known to accumulate high levels of mercury.

The most challenging aspect of this problem is discovering how to eliminate these compounds from the environment and where to focus remediation efforts. Even pollutants no longer in production persist in the environment, and bio-accumulate in the food chain. An understanding of how these chemicals, once in the environment, move through ecosystems, is essential to designing ways to isolate and remove them. Global efforts have been made to label the most common POPs routinely found in the environment through usage of chemicals like insecticides. The twelve main POPs have been evaluated and paced in a demographic so as to streamline the information around the general population. Such facilitation has allowed nations around the world to effectively work on the testing and reduction of the usage of these chemicals. With an effort to reduce the presence of such chemicals in the environment, they can no longer leach into food sources which contaminate the animals commercially fed to the U.S. population.

Perfluorooctanoic acid
PFOA is a stable chemical that has been used for its grease, fire, and water resistant properties in products such as non-stick pan coatings, furniture, firefighter equipment, industrial, and other common house hold items. There is evidence to suggest that PFOA is an endocrine disruptor affecting male and female reproductive systems. PFOA delivered to pregnant rats produced male offspring with decreased levels of 3-β and 17-β-hydroxysteroid dehydrogenase, a gene that transcribes for proteins involved in the production of sperm. Adult women have exhibited low progesterone and androstenedione production when exposed to PFOA, leading to menstrual and reproductive health issues.

PFOA exerts hormonal effects including alteration of thyroid hormone levels. Blood serum levels of PFOA were associated with an increased time to pregnancy—or "infertility"—in a 2009 study. PFOA exposure is associated with decreased semen quality. PFOA appeared to act as an endocrine disruptor by a potential mechanism on breast maturation in young girls. A C8 Science Panel status report noted an association between exposure in girls and a later onset of puberty

-Not breaking down and environmental issue/presence, bioaccumulation

BPA affects on pregnant women
To expand on the reproductive problems faced by women exposed to BPA. Studies in the US have shown that healthy women without any fertility problems found that urinary BPA was unrelated to time of pregnancy despite a shorter luteal phase (second part of the menstrual cycle) being reported. Additional studies have been conducted in fertility centers say that BPA exposure is correlation with lower ovarian reserves. To combat this most women will undergo IVF to help with the poor ovarian stimulation response and seemingly all of them have elevated levels of BPA in the urinary tract. Median conjugation of BPA concentrations were higher in those who did have a miscarriage compared to those who had a live birth. All of these studies show that BPA can have an affect on ovarian functions and the pivotal early part of conception. One study did show racial/ethnical differences as Asian women were found to have an increased oocyte maturity rate, but all of the women had significantly lower concentration of BPA just in this study.