User:Jocelyn Munson/sandbox

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Practice citations
p21, a protein that halts the cell cycle, is downregulated by histone deacetylase. Halting the cell cycle prevents the proliferation of tumors. Therefore, p21 has potential in preventing the spread of cancer. Histone deacetylase inhibitors upregulate p21 expression. Histone deacetylase inhibitors have been shown to be possible pancreatic cancer treatments.

Articles
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Brief summaries
hZimp10, a protein similar to PIAS, activates the tumor suppressor p53. This article also cites other studies relating to PIAS.

PIAS1 and PIAS3 inhibit NF-kappaB activity, which may aid in disease prevention.

PIAS1 may prevent adipogenesis via sumoylation, which may have implications in obesity treatment.

This article provides a general overview of PIAS, including its roles in sumoylation. It also describes PIAS's structural domains.

PIAS interacts with the TATA-binding protein

PIAS1 inhibits STAT-1 mediated gene activation in response to interferon.

JAK-STAT signaling pathway and autoimmune disease. There is also a diagram with the PIAS shown.

Infoboxes
click edit to get infobox template for proteins

Lead section
Introduction and summary of PIAS

History/Discovery
-Seminal papers/ timing for discovery placeholder

Structure
Known structural motifs:

-RING-finger-like zinc-binding domain (RLD)

-N-terminal SAP (contains LXXLL signature motif - all PIAS proteins have it)

-PINIT

-S/T

-AD/SIM

Mechanisms
-sumoylation

-recruitment of histone deacetylases

-preventing transcription factors from binding to DNA

-sending transcription factors to co-repressor complexes within the nucleus

Functions
-repression of NF-kappaB pathway

-inhibition of STAT

Applications in disease treatment
-obesity

-cancer

-inflammatory/autoimmune disease

Current Research
-placeholder