User:Joefished/Alpha-Fluoromethylhistidine

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α-Fluoromethylhistidine (α-FMH) is an irreversible specific inhibitor of histidine decarboxylase (HDC). It functions by forming a covalent linkage with a catalytic serine residue on the active site of HDC. It has potent sleep-inducing and food intake effects in mice. The mechanism for food intake regulation may proceed through enhanced expression ofneuropeptide Y (NPY) rather than through HDC inhibition.

α-FMH has also been shown to target isozymes of the glutathione S-transferase (GST) family. Due to the role of GSTs in detoxification, the efficacy of HDC inhibition by α-FMH is subject to further research.