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DHRS7B

Short-chain dehydrogenase reductase (SDR) family member 7B (DHRS7B) is a gene found on chromosome 17p11.2 and encodes a protein predicted to function in steroid hormone regulation. DHRS7B can also be referred to as DKFZp566O084, MGC8916, SDR32C1, and CGI-93.

Gene Features
DHRS7B is a member of the short chain dehydrogenase/reductase (SDR) superfamily and possesses, within its protein sequence, characteristic features of an SDR. The following table identifies sequences in the protein and corresponding function.

Gene Expression
Tissue expression in humans has been predicted for DHRS7B using microarrays. Gene expression is observed strongly in the testes, uterus, and intestine. There is moderate expression in the brain, pancreas, breast, and ovaries. Finally, there is little to no expression in circulating blood, bladder, and lymphatic tissues (spleen, thymus, and tonsil).



Disease
DHRS7B has been identified in the Smith-Magenis Syndrome region, a genetic developmental disorder linked to a deletion in chromosome 17p11.2. In breast cancer cells expressing CD44 and CD24, DHRS7B expression was observed to be down regulated. CD44 is an antigen found on the surface of most cell types and functions as a receptor that binds tissue macromolecules. Additionally, it acts as an adhesion molecule for leukocytes on peripheral lymphoid organs and inflammation sites. CD24 is associated with B-cells, epithelial cells, and dendritic cells, functioning as an adhesion molecule and shown to enhance a tumor cell's capability of metastasizing.