User:Jonathan6444/epigenetic clock sb

My two proposed edits:

Adding a section about epigenetic drift, and how it compares to epigenetic clock. Here are some notes


 * refers to a stochastic process that involves both gains and losses of the methylation state of CpG dinucleotides over time
 * genome-wide process and appears to be a collective phenomenon that correlates strongly with chronological age and appears to operate in a tissue-specific manner
 * 2 ways to measure tissue age
 * Drift occurs when the original methylation states of CpG dinucleotides are altered, presumably as a result of an error during the transfer of the epigenetic marks to the daughter strand following DNA replication.
 * methylation drift rate (a first order process)
 * the increase in variance of CpG methylation levels with age (a second order process)
 * application of epigenetic drift may be to ‘time’ the natural history of a specific disease and its progression through early and late states, thereby allowing a determination of the age (or sojourn time) of certain tissue abnormalities

Adding to the section subtitled: Relationship to a cause of biological aging


 * Doesn't really mention how biological aging is different and separate from chronological aging
 * Thus, an individual’s biological age, a proxy for an individual’s overall physiologic performance status and health status, can vary from his/her chronological age (28), displaying faster (acceleration) or slower (deceleration) aging rate, compared to normal aging
 * Chronological age, by definition, is a measure of the number of years an individual has lived. Yet, it is well appreciated that people age physiologically at different rates, and individuals of the same chronological age may have different biological ages
 * reflects the biophysiological aging status of the individual

''' I think this is a really interesting topic to dive into more deeply. Really cool proposal! '''

''' My concern is that the existing wikipedia article https://en.wikipedia.org/wiki/Epigenetic_clock is rather extensive and has been updated recently. How can you make this proposal a more substantial addition to the overall article? Outline something a little more extensive here. '''

--Trevor

Hi Trevor you make some good points. The bullet points are just small notes that I would like to highlight. My main addition, would be adding an entire section on epigenetic drift to the article (which I believe would definitely suffice).

The epigenetic drift would also have a few subsections (mechanism, comparison vs epigenetic clock, application of epigenetic drift).