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Physiological Reports is a peer reviewed scientific journal. It is an open access journal with all articles free to all readers. It is a collaboration between The Physiological Society and the American Physiological Society, who own the journal, and Wiley-Blackwell, who publish it. It is available online at Wiley Online Library, HighWire Press and PubMed Central.

Scope and publishing model
Papers are accepted solely on the basis of scientific rigor, adherence to technical and ethical standards, evidence that the data support the conclusions and being sufficiently well-conceived. Articles are published online-only using a continuous publication model in which papers are published in final form following proof correction. On publication each article is assigned to an issue, and each issue is closed at the end of the month.

History
The journal was launched in 2013, with an Editorial published on 27 March and receptions at two major international meetings, on 21 April at Experimental Biology (EB) 2013 in Boston, MA and on 22 July at IUPS 2013 (the XXXVII International Congress of Physiological Sciences) in Birmingham, UK. The first research paper was published on 7 May, and at the end of the first year a total of 178 research papers had been published. The Editor-in-Chief was Susan Wray of the University of Liverpool, UK and the Deputy Editor-in-Chief was Thomas Kleyman of the University of Pittsburgh, PA. The first research paper was published on 7 May, and at the end of the first year a total of 178 research papers had been published.