User:Jordynlazic/Cefazolin

Article body
There is no penetration into the central nervous system and therefore cefazolin is not effective in treating meningitis.

Spectrum of activity[edit]
Gram-positive aerobes:


 * Staphylococcus aureus (including beta-lactamase producing strains)
 * Staphylococcus epidermidis
 * Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus pneumoniae and other strains of streptococci

Gram-Negative Aerobes :


 * Escherichia coli
 * Proteus mirabilis
 * Klebsiella pneumoniae

Side Effects
Like those of several other cephalosporins, the chemical structure of cefazolin contains an N-methylthiodiazole (NMTD or 1-MTD) side-chain. As the antibiotic is broken down in the body, it releases free NMTD, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin K epoxide reductase) and a reaction with ethanol similar to that produced by disulfiram (Antabuse), due to inhibition of aldehyde dehydrogenase. Those with an allergy to penicillin may develop a cross sensitivity to cefazolin.