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= (R)-2-methylpent-4-enoic acid = (R)-2-methylpent-4-enoic acid is an organic acid with the chemical formula C6H10O2. Other names for this molecule include (R)-2-Methyl-4-pentenoic acid, (R)-(-)-2-Methyl-4-pentenoic acid, and methylallylacetic acid.

Synthesis
(R)-2-methylpent-4-enoic acid can be synthesized using a chiral auxiliary such an oxazolidinone derivative, popularized by David Evans. One route of synthesis consists of three steps:


 * 1) acylation of the oxazolidinone using triethylamine as a base, and DMAP as an acyl carrier catalyst
 * 2) addition of a pentene group via enolate addition using Sodium bis(trimethylsilyl)amide as a base and allyl iodide as the pentene donor
 * 3) and cleavage of the oxazolidinone by LiOH solution in hydrogen peroxide and sulfite to reduce the peroxide to the acid.

Uses
(R)-2-methylpent-4-enoic acid can also be used in synthesis of other chiral compounds. For example, it has been used in the process of synthesizing the drug Sacubitril as a reagent for adding a chircal center to the molecule.