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Protein toxicity has a significant role in neurodegenerative diseases. Whether it is due to high protein intake, pathological disorders lead to the accumulation of protein waste products, the no efficient metabolism of the proteins, or oligomerization of the amino acids from proteolysis. The mechanism by which protein can lead to well know neurodegenerative diseases includes transcriptions dysfunction, propagation, pathological cytoplasmic inclusions, mitochondrial and stress granule dysfunction.

Chung CG, Lee H, Lee SB. Mechanisms of protein toxicity in neurodegenerative diseases. Cell Mol Life Sci. 2018;75(17):3159-3180. doi:10.1007/s00018-018-2854-4

Delimaris I. Adverse Effects Associated with Protein Intake above the Recommended Dietary Allowance for Adults. ISRN Nutr. 2013;2013:126929. Published 2013 Jul 18. doi:10.5402/2013/126929

= Peak week recommendations for bodybuilders: an evidence based approach = Guillermo Escalante 1, Scott W Stevenson 2, Christopher Barakat 3 4, Alan A Aragon 5, Brad J Schoenfeld 6

Affiliations


 * PMID: 34120635


 * PMCID: PMC8201693


 * DOI: 10.1186/s13102-021-00296-y

= Effect of Dietary Protein Levels on the Toxicity and Metabolism of Heptachlor = W. M. Weatherholtz, T. C. Campbell, R. E. Webb

Author Notes

The Journal of Nutrition, Volume 98, Issue 1, May 1969, Pages 90–94, https://doi.org/10.1093/jn/98.1.90

Published:

01 May 1969