User:Js3377/Calcium channel/Rjcam2 Peer Review

General info
Js3377
 * Whose work are you reviewing?


 * Link to draft you're reviewing:User:Js3377/Calcium channel
 * Link to the current version of the article (if it exists):Calcium channel

Evaluate the drafted changes
Lead:

- Your addition to the second sentence, "although there are also second messenger regulated calcium channels which can be modified by the binding of a ligand" is a bit wordy. You talk about ligand-gated channels without directly mentioning the term. I think it would be more concise to just establish that calcium channels can be voltage-gated or ligand-gated. This will help the reader with the organizational structure of the article too. - I think the word choice for "modified" is a little misleading when used with voltage and ligands. When I think of using the word modified, I think of protein modifications such as phosphorylation or glycosylation. I would use a different word.

-The example of a Cat-Sper cation channel seems a little out of place for the lead paragraph. I would consider using it as an example for a section talking about regulatory sites or something along those lines. It's a little too detailed for this section and is mentioned no where else in the article.

-Try to simplify the next two sentences (about generating action potentials and triggering second messenger cascades). Instead of talking about Cat-Sper channels specifically participating in generating action potentials, maybe just generally state that calcium channels can depolarize cell membranes and also activate second messenger cascades. Basically, simplify your sentences to introduce their role in these functions.

-Last sentence seems to be referring to nonselective cation channels. I would directly use the term and make sure these types of channels are referred to in the article body somewhere.

Content: The content you've added so far is good and up-to-date. Are you going to keep the section "Other channels permeable to Calcium" as the subheading? Or is this referencing nonselective cation channels. If so, I would change the section title.

Tone/Balance: Great job using a neutral tone.

Sources and References: The link for your last reference (Trudeau, Jie Zheng, Matthew C.; 2023) didn't work for me. It showed an error message. Otherwise source selection is good and up-to-date.

Organization: Again, I think you can make the sentences in your Lead more clear and concise by referencing specific terms directly and some change in word choice. I did like that you changed P2X receptors into a different section.

Images: Please add your figure.

Overall: good job adding some details regarding channel function and regulation. I'd like to see some of the details added in the Lead to maybe a new section discussing regulation maybe. I think it was good that you distinguished nonselective cation channels that are permeable to calcium as a different type of channel.