User:Jsjsjs1111/sandbox

ClinicalTrials.gov NCT01315847 Position Emission Tomography Study of Brain CGRP Receptors After MK-0974 Administration (MK-0974-067 AM1)

Clindamycin
When and how was Clindamycin discovered?--Jsjsjs1111 (talk) 05:37, 22 June 2012 (UTC)
 * This article from 1970 says that the drug was "newly developed" from lincomycin. 203.27.72.5 (talk) 06:32, 22 June 2012 (UTC)
 * (edit conflict) 1966, modified from Lincomycin ("Chemical Modifications of Lincomycin", Antimicrobial Agents and Chemotherapy (1961-70) (1966), 1966, 727-36.), is the earliest reference I can find to it. Buddy431 (talk) 06:41, 22 June 2012 (UTC)
 * Here's a 1970 paper on its synthesis. It probably has the information you're looking for, but it's behind a pay wall. 203.27.72.5 (talk) 06:42, 22 June 2012 (UTC)
 * Apparently its synthesis was first announced in 1965 at the Fifth interscience conference on antimicrobial agents and chemotherapy by Robert Birkenmeyer, et al. 203.27.72.5 (talk) 06:50, 22 June 2012 (UTC)
 * Thank you very much! BTW, your IP address looks oddly familiar. You're from Brisbane?--Jsjsjs1111 (talk) 07:20, 22 June 2012 (UTC)
 * I'm in the NT, but my organisation is headquartered in Brisbane, so maybe that has something to do with it. 203.27.72.5 (talk) 07:23, 22 June 2012 (UTC)

Pregnancy category of Ethanol?
On Drugs in pregnancy it is said that Ethanol is in Category X, but on Ethanol article it is in Category C. Googling yields mixed result too. I changed it to Category X because of Fetal alcohol spectrum disorder but somebody reverted it saying that it is Category C on drugs.com.--Jsjsjs1111 (talk) 08:17, 24 June 2015 (UTC)


 * I can not find any evidence that the United States Food and Drug Administration maintains any listing for ethanol regarding "pregnancy category" (as defined in 21 CFR 201.57). Instead, they have information about rules for labeling drugs, the "Pregnancy and Lactation Labeling Rule."
 * Furthermore, the FDA does not regulate or label ethanol in the United States. This is not an indication of its category as a drug, nor in any way a reflection of its health risks.  For purely historical reasons, alcohol is regulated at state levels in the United States, and at the Federal level by a totally different agency (the Bureau of Alcohol, Tobacco, Firearms and Explosives).  The FDA is very careful not to overstep its mandate in this matter: see, for example, FDA's published Memorandum of Understanding Between The Bureau of Alcohol, Tobacco and Firearms and The Food and Drug Administration regarding the Promulgation and Enforcement of the Labeling Regulations Promulgated under the Federal Alcohol Administration Act (if you love reading fine print!)
 * So: any website that lists a "pregnancy category" for ethanol and attributes it to FDA should cite an FDA website. If they do so, they probably will not find any information placing Ethanol in any category at all.  "drugs.com" is not an affiliated with the FDA, nor is it an official publication of the FDA; and in my opinion, it does not meet requirements to qualify as a reliable encyclopedic source.  For the record, this website also lists ethanol as a "prescription drug," which is absolutely false in the United States.  That website is full of auto-generated junk and should not be cited on Wikipedia.
 * Let me restate this rather more emphatically: random internet websites do not have standing to label a drug in Category C or X. Only the FDA can do that.  The FDA has not placed ethanol in either category, and probably will never do so, because they choose not to enforce labeling rules for ethanol at all.
 * Nimur (talk) 13:00, 24 June 2015 (UTC)

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