User:Juntaoluo/sandbox

Teolodendrimer refers to a linear-dendritic block copolymer. The term of "Telodendrimer" was coined by Dr. Juntao Luo in 2009 when he was a research chemist in Dr. Kit S. Lam's Laboratory in University of California, Davis. Linear-dendritic block copolymers have been reported before pioneered by Professor Jean M.J. Fréchet. Telodendrimer is a hybrid structure, combining the chemical diversity and precise structure as small molecule, peptide and dendrimer, as well as the self-assembly properties of amphiphilic copolymers for nanoparticle formation in drug delivery. is not a classic polymer: it has well defined structure and the chemical diversity of telodendrimer are whose properties depend on and are limited by the monotonic chemistry of the repeat units. In contrast, telodendrimer has tunable, well-defined, and highly engineerable structure and architectures; Further, it is not a dendrimer, which normally can’t self-assemble into nanoparticle for drug delivery. Dr. Juntao Luo introduce an unique facial amphiphilic building block cholic acid, a biosourced surfactant in our guts for digestion, into the periphery of telodendrimer, which can stabilize nanoparticle formed by telodendrimer for drug delivery. Further, the new architecture and functionality of telodendrimer been further developed for structure-based nanocarrier design. Specific drug-binding moieties can be introduced on the peripheral of telodendrimer stabilized by alternating cholic acid motives or a segregated cholic acid intermediate layer groups can be introduced together with cholic acid