User:Justanotherstudenthere/Chartreusin

Biological Activity
Chartreusin was shown to be effective as an antibitotic against some gram-positive species, as well as mycobacteria. This compound has also displayed anti-cancer activity, particularly against certain melanomas and leukemias in mice. However, this effect could only be observed in-vivo when the antibiotic was administered via intraperitoneal injection. Chartreusin administered by intravenous therapy was ineffective, as the compound would be excreted via bile.

Chartreusin is believed to function by binding directly to DNA, preventing its replication. In particular, it binds cooperatively and with alternating AT or GC sequences. Upon binding, Chartreusin may inhibit the relaxation of negatively supercoiled DNA, or induce strand scission. When introduced to mammalian cells,