User:K.S.V. Krishna Rao

Dr Krishna Rao did his PhD on Interpentrating polymeric network systems: the developed Polymeric Matrices used for Controlled Release of Drugs and Pervaporation.

Polymeric matrices in Drug delivery:

Actually Drug delivery occurs when a polymer whether a synthetic or natural is judicially combined with a drug or other active agent in such a way that the active agent is released from the material in predesigned manner

Purpose of Drug delivery

Delivering the drugs through targeted sites

Maintaining the drug level within the desired range

Need for fewer administration

Increased patient compliance

Release the drug for longer periods with fewer side effects.

In this part, Dr Krishna Rao have used natural polymers (Sodium alginate, Chitosan, Hydroxy ethyl celluloce) and synthetic polymers (PVA, PVP and PMMA) an monomers (Acryl amide, MMA, acrylamido glycolic acid etc.). By using these I have prepared; hydrogels, beads microgels as well as submicron size particles for controlled release applications. These polymers are used to prepare (make) micro particles with Non steroidal anti-inflammatory, antibiotic, anticancer etc. The characterization of these matrices was confirmed via, FTIR, DSC, SEM Particle size analyzer and X-rd.

Polymeric membranes in pervaporation:

Pervaporation: Pervaporation is a method for the separation of mixtures of liquids by partial vaporization through a non-porous perm-selective membrane.

Pervaporation is used in situations where distillation is not possible, difficult or uneconomic.

Applications:

§  Pervaporation and vapour permeation are used for an effective and economic separation of mixtures of substances with small volatility differences (boiling point) azeotropic mixtures.

§  Ethanol dehydration (Bio ethanol, Fuel Ethanol power ethanol)

§  Solvent dehydration (Alcohol, Ketones, Easters...)

§  Water removal from condensation reactions

§  Methanol (or water or ethanol removal from transesterification reactions)

Dr Krishna Rao have prepared mixed matrix, blend and semi-IPN membranes with natural polymers.

These membranes used for dehydration of Acetic acid, Isopropanal, 1,4-dioxane, THF and acetic acid.

The research output has been published in around 85 national and international publications.