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Conway joined Xerox PARC in 1973, where she led the "LSI Systems" group under Bert Sutherland. When in PARC, Conway founded the "multiproject wafers" (MPW). This new technology made it possible to pack multiple circuit designs from various sources into one single chip. Her new invention increased production and decreased costs. Collaborating with Carver Mead of Caltech on VLSI design methodology, she co-authored Introduction to VLSI Systems, a groundbreaking work that would soon become a standard textbook in chip design, used in nearly 120 universities by 1983. With over 70,000 copies sold, and the new integration of Lynn's MPC79/MOSIS innovations, the Mead and Conway revolution became part in VLOSI design. copied from Lynn Conway

Among Conway's contributions were invention of dimensionless, scalable design rules that greatly simplified chip design and design tools,  and invention of a new form of internet-based infrastructure for rapid-prototyping and short-run fabrication of large numbers of chip designs. The new infrastructure was institutionalized as the MOSIS system in 1981. Two years into its success, Mead and Conway received the Electronics Magazine's annual award of achievement. Since then, MOSIS has fabricated more than 50,000 circuit designs for commercial firms, government agencies, and research and educational institutions around the world. Prominent VLSI researcher Charles Seitz commented that "MOSIS represented the first period since the pioneering work of Eckert and Mauchley on the ENIAC in the late 1940s that universities and small companies had access to state-of-the-art digital technology." copied from Lynn Conway

While struggling with life in a male role, Conway had been married to a woman and had two children. Under the legal constraints then in place, she was denied access to her children after transitioning. copied from Lynn Conway

She has provided direct and indirect assistance to numerous other transgender women going through transition and maintains a well-known website providing medical resources and advice. copied from Lynn Conway