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Myristicin is a naturally occurring compound found in common herbs and spices, the most well known being nutmeg. It is an insecticide, and has been shown to enhance the effectiveness of other insecticides in combination. Myristicin is also a precursor for amphetamine derivative compounds such as MDMA; it is believed to be metabolized into MMDA in the body to produce hallucinogenic effects, and can be converted to MMDMA in controlled chemical synthesis. It interacts with many enzymes and signaling pathways in the body ,  is cytotoxic to living cells , and may also have chemoprotective properties.

Uses
Isolated myristicin has proven an effective insecticide against many agricultural pests, including Aedes aegypti mosquito larvae, Spilosoma obliqua (hairy caterpillars), Epilachna varivestis (Mexican bean beetles), Acyrthosiphon pisum (pea aphids), mites, and Drosophila melanogaster (fruit flies). Myristicin was shown to be an effective repellant, and to cause mortality via direct and systemic exposure. It also displayed a synergistic effect when administered to insects in combination with existing insecticides.

The structure of myristicin closely resembles that of amphetamine compounds, and it is capable of producing psychotropic effects similar to MDMA compounds. Because of this, it can be used in synthetic synthesis to create amphetamine derivatives, and create designer drugs like MMDMA that are similar in structure and effect to MDMA. Out of the common spices that contain myristicin, nutmeg has the highest relative concentration of the compound. Therefore, it is used most frequently to isolate myristicin or exploit its effects. While there are accidental nutmeg poisonings, it is also known to be abused with the intention of achieving a low cost high resembling psychedelics, particularly by adolescents, drug users, college students, and prisoners. Relatively large doses of nutmeg are required to produce effects, therefore a majority of reported nutmeg intoxication cases appear to be the result of intentional abuse.

Furthermore, myristicin interferes with multiple signaling pathways and enzyme processes in the body. It is toxic to cells and also may have chemoprotective properties, making it an interesting topic for further pharmacological or therapeutic research. [See Pharmacology, Toxicity]

Psychoactive Effects
The psychotropic potential of myristicin is believed to emerge when it is metabolized into MMDA, an amphetamine derivative that is reported to have a more potent hallucinogenic effect than mescaline. There is more research needed on the exact mechanism of action of myristicin in the body. Documented symptoms include anxiety, fear, a sense of impending doom, detachment from reality, acute psychotic episodes, visual hallucinations (time, color, or space distortions) and hostile, combative, agitated behavior. There have been cases of prolonged use leading to chronic psychosis. With a chemical structure resembling amphetamines and other precursors, myristicin can also be used to synthesize illicit hallucinogenic drugs. Under controlled conditions, myristicin isolated from nutmeg oil can be converted into MMDMA, a synthetic "designer drug" amphetamine derivative that is less potent than MDMA but produces comparable stimulant and hallucinogenic effects. A 400 mg dose of myristicin has been shown to produce “mild cerebral stimulation” in 4 out of 10 human subjects. Myristicin is most commonly consumed in nutmeg, and 400 mg would be contained in approximately 15 g of nutmeg powder. However, at a minimum dose of about 5 g of nutmeg powder, symptoms of nutmeg intoxication can begin to emerge, indicating the interaction of other compounds contained in nutmeg. Elemicin and Safrole are also components of nutmeg that, while at lower concentrations than myristicin, are thought to contribute to the hallucinogenic and physiological symptoms of nutmeg intoxication.

Toxicity
Myristicin has been proven to be cytotoxic, or toxic to living cells. Specifically, it stimulates cytochrome c release, which activates caspase cascades and induces early apoptosis in the cells. However, it has been proven that myristicin does not have genotoxic potential in metabolically active human hepatocellular carcinoma cells, meaning it likely does not cause mutations in genetic material.

In human neuroblastoma SK-N-SH cells, myristicin led to apoptosis and observable morphological changes, as well as chromatin condensation and DNA fragmentation. This indicates a definite cytotoxic effect, and a potential neurotoxic effect that requires further investigation.

Myristicin has also been shown to inhibit cytochrome P450 enzymes in humans, which is responsible for metabolizing a variety of substrates including hormones and toxins, allowing these substrates to accumulate. This can compound its own toxicity and/or lead to increased bioavailability of other substances, which can lower the threshold for overdose from other drugs that may be in the body.

The effects of nutmeg consumed in large doses are attributed mostly to myristicin, where 1-7 hours following ingestion symptoms include disorientation, giddiness, stupor, and/or stimulation of the central nervous system leading to euphoria, intense hallucinations that alter one's orientation to time and surroundings, feelings of levitation, loss of consciousness, tachycardia, weak pulse, anxiety, and hypertension. Symptoms of nutmeg intoxication further include nausea, abdominal pain, vomiting, dryness of mouth, mydriasis or miosis, hypotension, shock, and potentially death.

Myristicin poisoning can be detected by testing levels of myristicin in the blood. There are currently no known antidotes for myristicin poisoning, and treatment focuses on symptom management and potential sedation in cases of extreme delirium or aggravation.

Pharmacology
Myristicin is soluble in ethanol and acetone, but insoluble in water

Myristicin is additionally known to be a weak inhibitor of monoamine oxidase (MAO), a liver enzyme in humans that metabolizes neurotransmitters (e.g., serotonin, dopamine, epinephrine, and norepinephrine). It lacks the basic nitrogen atom that is typical of MAO inhibitors (MAOIs), potentially explaining a weaker inhibitory effect.

While smaller concentrations of MAOIs may not cause problems, there are additional warnings regarding drug interactions. Those taking antidepressants that are MAOIs (e.g. Phenelzine, Isocarboxazid, Tranylcypromine, Selegiline ) or taking selective serotonin re-uptake inhibiting (SSRI) antidepressants should avoid essential oils rich in myristicin, such as that of nutmeg or anise. The combination of myristicin with these drugs produces an additive inhibition of MAO, which can cause serotonin levels in the brain to rise to dangerous levels under certain circumstances. This may lead to a condition called serotonin syndrome, which can be dangerous and potentially fatal.

Myristicin has also been shown to have anti-cholinergic activity, therefore symptoms of myristicin poisoning overlap largely with those of anticholinergic toxicity. It is thought that myristicin frequently leads to miosis while mydriasis is more typical of anticholinergic toxicity, but there is more research needed on this distinction.

Myristicin also has potential chemoprotective properties. In mouse liver and small intestine mucosa, myristicin induced higher levels of glutathione S-transferase (GST), which catalyzes a reaction that detoxifies activated carcinogens. This indicates that myristicin may act as an inhibitor of tumorigenesis. It is still unknown how much the tendency of myristicin to induce apoptosis in cells contributes to its chemoprotective abilities.