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Irving M. Klotz (January 22, 1916 – April 27, 2005) was an American chemist. He was noted particularly for his work on proteins, using concepts drawn from physical chemistry to understand their interactions with other molecules.

Early life and education
Klotz studied Chemistry at the University of Chicago, obtaining a S.B. in 1937 and a Ph.D. in 1940.

Career
In late 1940, Klotz became a research associate at Northwestern University, where he would spend the rest of his career. Unlike a typical postdoctoral appointment, he worked on secret wartime research projects selected by the National Defense Research Committee and taught two classes. He continued various NDRC projects involving gasses, filters, and the use of spectrophotometric methods for the rest of the war, including after his 1942 appointment as an instructor.

Original, now in its seventh edition.

Klotz engaged in skeptical inquiry.

Honors and awards
Klotz was the recipient of the 1949 American Chemical Society Eli Lilly Award in Biological Chemistry, He was elected a fellow of the American Academy of Arts and Sciences in 1968, a member of the National Academy of Sciences in 1970, and a fellow of the Royal Society of Medicine in 1971.

Personal life
In 1947, he married Themis Askounis Klotz, with whom he had a son, Edward, and a daughter, Audie. In 1966, he married Mary Sue Hanlon Klotz, later a professor of Biochemistry and Molecular Genetics at the University of Illinois at Chicago, with whom he had a son, David.