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Practice Editing Here (Nov 23rd in-class Wiki session work)

 * This is a place to practice clicking the "edit" button and practice adding references (via the citation button).

Amyloidosis

Assignment # 3
 Assignment 3: Wikipedia Page Improvement Plan (Individual Assignment) 

https://en.wikipedia.org/wiki/Amyloidosis (treatment section)

 Targeted sentence:  “In ATTR, liver transplant is a curative therapy because mutated transthyretin which forms amyloids is produced in the liver. ”

 Proposed Changed: 

Management of ATTR amyloidosis will depend on its classification as wild type or variant. Both may be treated with tafamidis, a low toxicity oral agent that prevents destabilization of correctly folded protein. Studies showed tafamidis reduced mortality and hospitalization due to heart failure. Previously, for variant ATTR amyloidosis, liver transplant was the only effective treatment. However, newer therapies including Diflunisal, an anti-inflammatory drug, and Inotersen and Patisiran, drugs which prevent misfolded protein formation, have shown early promises in slowing disease progression. The latter two drugs have shown their benefit in neurological impairment scores and quality of life measures. However, their role in cardiac ATTR amyloidosis is still being investigated.

 Rationale for proposed change: 

This sentence was outdated.

The supporting reference is from 1997 and management has evolved since then.

Newer agents have emerged that have demonstrated effects on slowing disease progression.

This sentence is incomplete

The sentence does not differentiate between wild type and variant type ATTR amyloidosis which have some differences in management.

Also, it did not specifically describe the benefits of treatment including the mortality and quality of life.

Source: Gertz MA, Dispenzieri A. Systemic Amyloidosis Recognition, Prognosis, and Therapy: A Systematic Review. Jama. 2020 Jul 7;324(1):79-89.

 Critique of Source 

Some authors of the paper serve on the boards and receive funding from drug companies.

This is a potential source of bias as these drug companies have an interest in which drugs are used for the treatment of disease.

I briefly looked into supporting references and they seem to support their claims, so I went ahead with the changes.

Much of the information on the new medications and their role in management is still being uncovered therefore the language of the proposed changes emphasizes that these are early promises.

What to post on the talk page?

 * This will also be covered on Nov 23rd in class. Your group should use the below template to share an outline of your proposed improvements (including your new wording and citations). Article talk pages are not places to share your assignment answers. The Wikipedia community will be more interested in viewing your exact article improvement suggestions including where you plan to improve the article (which section), what wording you suggest, and the exact citation (Note: all citations must meet WP:MEDRS)
 * You will not be able to paste citations directly from your sandbox to talk pages (unless you are interested in editing/learning Wiki-code in the "source editing" mode). We suggest re-adding your citations on the talk page manually (using the cite button and populating the citation by pasting in the DOI, website, or PMID). You will have to repeat this process yet again when you edit the actual article live.
 * Talk Page Template: CARL Medical Editing Initiative/Fall 2020/Talk Page Template