User:Kathryn l hughes/sandbox

https://en.m.wikipedia.org/wiki/Inflammation

Here is a list of what we would like to accomplish:

Hyo

-Addition of an ‘injury’ section to inflammation

-overarching structure of article is problematic: how does major textbook or site organize/emphasize inflammation? Maybe we could restructure it to look more like that

Ashwin

-”Functio laesa is an apocryphal notion” - No one knows what apocryphal means.

-’Systemic inflammation and overeating’ contains too many lengthy quotations

-Allergy section (Inflammatory Disorders) can be expanded

Kylie

-better pictures

-“cardinal signs”, perhaps expand that section to acute vs. chronic inflammation under it, keeping a short section on the general signs of inflammation (calor, rubor, etc)

Katie:

-Lack of citation in: Causes section & Types section

- Add tryptase to list of cell derived mediators of inflammation (with citations below)

- add “Mast Cell Activation Syndrome” and “Systemic Mastocytosis” to list of inflammatory disorders

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KATIE'S STUFF

Citation for physical injury as a cause of inflammation: Granger DN, Senchenkova E. Inflammation and the Microcirculation. San Rafael (CA): Morgan & Claypool Life Sciences; 2010. Chapter 9, Coagulation and Thrombosis. https://www.ncbi.nlm.nih.gov/books/NBK53380/.

Adding Mast Cell Activation Syndrome and Mastocytosis to list of inflammatory disorders:

Mast Cell Activation Syndrome

Systemic Mastocytosis

Tryptase as marker of inflammation from mast cells: Cevikbas F, Kempkes C, Buhl T, et al. Role of Interleukin-31 and Oncostatin M in Itch and Neuroimmune Communication. In: Carstens E, Akiyama T, editors. Itch: Mechanisms and Treatment. Boca Raton (FL): CRC Press/Taylor & Francis; 2014. Chapter 13. Available from: https://www.ncbi.nlm.nih.gov/books/NBK200913/

Caughey GH. Mast cell tryptases and chymases in inflammation and host defense. Immunological reviews. 2007;217:141-154. doi:10.1111/j.1600-065X.2007.00509.x.

Caughey GH. Mast cell proteases as pharmacological targets. European journal of pharmacology. 2016;778:44-55. doi:10.1016/j.ejphar.2015.04.045.

In table: Name = Tryptase, Type = Enzyme, Source = mast cells, Description = "This serine protease is believed to be exclusively stored in mast cells and secreted, along with histamine, during mast cell activation."

_____________________________________________________________ __--GOAL: MAKE ARTICLE MORE READ-ABLE AND INCORPORATE RELEVANT IMAGES-- -Removed the hyperlink at the top of the page for an obscure Turkish film entitled "Inflame"--irrelevant information that added clutter -Switched photo at the top of the page from a histology slide to an example of a foot experiencing inflammation -Added to the inflammatory disorders section and added images of some of the examples (Asthma and Colitis) -Corrected misspellings throughout article and removed extraneous sentences

Cardinal signs[edit | edit source]
Acute inflammation is a short-term process, usually appearing within a few minutes or hours and begins to cease upon the removal of the injurious stimulus. It involves a coordinated response of various immune, endocrine and neurological mediators of acute inflammation. In a normal healthy response, it becomes activated, clears the pathogen, begins the repair process, and then ceases. It is characterized by the following five cardinal signs, which were derived from Latin: * An acronym that may be used to remember the key symptoms is "PRISH", for pain, redness, immobility (loss of function), swelling and heat. The first four (classical signs) were described by Celsus (ca. 30 BC–38 AD), while loss of function was added later by Galen even though the attribution is disputed and the origination of the fifth sign has also been ascribed to Thomas Sydenham and Virchow. Redness and heat are due to increased blood flow at body core temperature to the inflamed site; swelling or edema is caused by accumulation of fluid; pain is due to the release of chemicals such as bradykinin and histamine that stimulate nerve endings. Loss of function has multiple causes. ← Previous edit___________________________________________
 * Dolor (pain)
 * Calor (heat)
 * Rubor (redness)
 * Tumor (swelling)
 * Functio laesa (loss of function)