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Prophylactic salpingectomy is a preventative surgical technique performed on patients who are at higher risk of having ovarian cancer, such as individuals who may have the BRCA1 or BRCA2 gene. Originally salpingectomy’s were used in cases of ectopic pregnancies. As a preventative surgery however, it involves the removal of the fallopian tubes. By not removing the ovaries this procedure is advantageous to individuals who are still of child bearing age. It also means risks such as cardiovascular disease and osteoporosis which are associated with removal of the ovaries are reduced.

Indications
In 2013 in America alone there were 22,000 cases of ovarian cancer diagnosed and reported. Of these 10% were due to an inherited disorder. It is also the fifth most common cancer related cause of death in women. The BRCA1 and BRCA2 genes are the most common inherited genetic mutations which lead to ovarian cancer. As such a preventative surgery such a prophylactic salpingectomy is thought to decrease this risk of getting cancer. Recent research has shown that ovarian cancer may not originate in the ovaries themselves but start in the fallopian tubes (Venturella et al., 2015). It is therefore thought that in women who are of child bearing age the more common salpingo-oophorectomy may not be the correct surgery of choice. Adapted from

Clinical Evidence
adada

Surgical risks
aa

Long-term effects
sss

IVF after salpingectomy
aa

Effects on testosterone
aa

Delayed oophorectomy
Early salpingectomy with delayed oophorectomy allows for the postponement of premature surgical menopause and is therefore associated with an improved quality of life [1].

Emergency salpingectomy
Lcaparotomy with salpingectomy is the recommended treatment for ectopic pregnancy [2].

Bilateral salpingo-oophorectomy
Currently, the only intervention proven to reduce ovarian cancer risk is bilateral salpingo-oophorectomy (BSO) at age 35–40 for BRCA1 carriers or age 40–45  for BRCA2, which has been shown to decrease incidence by 80-96% [1]. During BSO both ovaries and both fallopian tubes are removed in one operation. However, only 60-70% of BRCA mutation carriers undergo BSO currently, which is related to the generation of premature surgical menopause in the patient and the associated risks of oestrogen deficiency, urogenital atrophy, osteoporosis, and cardiovascular disease [1].