User:Kelsidc/Epigenetics of autism/SShrestha Peer Review

General info

 * Whose work are you reviewing?

Kelsidc


 * Link to draft you're reviewing
 * User:Kelsidc/Main Sandbox


 * Link to the current version of the article (if it exists)
 * Epigenetics of autism

Lead
The new contributions to the lead are more confident than the original article. I appreciate the additions of excerpts from the ICD-11 that helps us understand what ASD is through characteristics rather than just some examples as the original article lead gave. I noticed that the mechanisms were briefly mentioned in the lead and are explored more in the content. Possibly revisit that and consider separating mechanisms into its own paragraph in the lead.

Content
I think the reorganizing on the section from chromosome 15 to cortical hyperexcitability makes it more organized and easy to understand. It starts with the broad perspective and gives details.

Important additions on HDACs, surprising that it wasn't there before. I like the contributions to this section, but it could be organized better. I think the section focused on VPA model could be separated as a subheading under HDACs, maybe the subheading could be about prenatal exposure to HDAC inhibition.

I think the section about the X chromosome from the original article could also be edited. The research cited on that section is roughly 20 years old. There might be some updates on the epigenetic research. I also think that this section might be a good spot to elaborate on the misdiagnosis of girls with autism mentioned in the lead section.

Tone and Balance
Content was neutral, I didn't sense there was any argument towards a certain perspective.

Sources and Reference
References seem to rely on published, reviewed papers and government websites. Some references are missing the year they were published.