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Sperm Granuloma Treatment and Prevention
Most sperm granulomas are asymptomatic and are absorbed over time. However, in more severe cases, non-steroidal anti-inflammatory drugs such as Ibuprofen can be used. Surgery is very rarely performed.

There are instances in which sperm granulomas are mistaken for other conditions, such as testicular tumors. In these instances, a more complicated treatment approach such as an orchiectomy may be accidentally used.

Sperm granulomas can also be mistaken for supernumerary testis (the presence of more than two testes).

Cauterization is vasectomy method used to seal the vas deferns by utilizing heat or electricity to burn the lumen. Using thermal (heat) cautery instead of electrocautery can help prevent granulomas and nodular thickening.