User:Kmhoque

Mirajul H. Kazi, Ph.D. is an outstanding research scientist in the field of Gastrointestinal Physiology. He is a graduate of Jadavpur University, Kolkata, India, was a Senior Research Fellow of ICMR at the National Institute of Cholera & Enteric Diseases (NICED), Kolkata. After two years at the Yale University School of Medicine for initial postdoctoral training with Prof. Henry Binder, MD and 5 years at the Johns Hopkins University School of Medicine, Dr. Mirajul H. Kazi returned to NICED as a Research Scientist and Ramalingaswami Fellow in 2010. Prior to his time at NICED, Dr. Kazi was on entry level faculty as instructor of Medicine at the Gastroenterology Division of the Johns Hopkins University School of Medicine. Dr. Kazi has had research interest to understanding the mechanism of intestinal electrolyte transport in health and disease, focus on absorptive and secretory process and functional regulation of epithelial tight junction. Several of his noteworthy observations include establishing that zinc inhibits chloride secretion by inhibiting basolateral potassium channel(s) which explain the beneficial effects of zinc in the treatment of acute and persistant diarrhea in children. He is currently investigating the role of a new player called Epac (Exchange protein directly activated by cAMP) in epithelial ion transport (transcellular vs. paracellular) and tight junction function and its role in diarrhea. This is an emerging area that should allow to provide new insights understanding of intestinal ion transport. Certainly he is now considered as world class research scientist in gastrointestinal diseases.