User:Kmostov/sandbox

Keith E. Mostov is an academic cell and developmental biologist, who has been on the faculty of the University of California, San Francisco, School of Medicine since 1989.

Biography

Mostov was born in New York City in 1956. He received an AB from University of Chicago in 1976 and was a Rhodes Scholar at New College, Oxford.

https://www.nytimes.com/1976/09/30/archives/new-jersey-pages-rhodes-scholars-from-a-playwright-to-a-soldier.html?searchResultPosition=3

Mostov received a PhD in Biological Science from the Rockefeller University in the laboratory of Nobel laureate Guenter Blobel in 1983,

https://en.wikipedia.org/wiki/Günter_Blobel

and an MD from Weill Cornell Medicine in 1984. He was a Whitehead Fellow at the Whitehead Institute of MIT from 1984 to 1989.

https://wi.mit.edu/select-past-fellows

In 1989, Mostov joined the faculty of the University of California, San Francisco, School of Medicine, where he is currently a Professor in the Departments of Anatomy, and Biochemistry/Biophysics.

https://profiles.ucsf.edu/keith.mostov

Contributions to Science

1. Mostov and colleagues discovered the Polymeric Immunoglobulin Receptor (pIgR).

https://en.wikipedia.org/wiki/Polymeric_immunoglobulin_receptor

Proc. Natl Acad Sci USA. 1980 Dec;77(12):7257-61. doi: 10.1073/pnas.77.12.7257. PMID: 6938972

They proposed that newly made pIgR is first sent to the basolateral surface of the cell, where it can bind polymeric IgA or IgM (pIg). The pIg-pIgR complex is then endocytosed, transcytosed across the cell in vesicles, and exocytosed at the apical surface, where the Secretory Component is proteolytically cleaved off from the pIgR, releasing Secretory Component together with the pIg.

2. Mostov and colleagues cloned and sequenced the pIgR. They found that the Secretory Component portion of the pIgR contains five immunoglobulin-like domains.

Nature. 1984 Mar 1-7;308(5954):37-43. doi: 10.1038/308037a0. PMID: 6322002 Nature. 1984 Mar 1-7;308(5954):12-3. doi: 10.1038/308012a0. PMID: 6700707

3. Mostov and colleagues used the pIgR to study the signals for membrane traffic and transcytosis in polarized epithelial cells.

Cell. 1986 Nov 7;47(3):359-64. doi: 10.1016/0092-8674(86)90592-1. PMID: 3768957

They showed that the cytoplasmic domain of the pIgR contains a signal for basolateral sorting.

Cell. 1991 Jul 12;66(1):65-75. doi: 10.1016/0092-8674(91)90139-p. PMID: 2070419 Nat Cell Biol. 2012 Dec;14(12):1235-43. doi: 10.1038/ncb2635. PMID: 23196841

They further found that binding of IgA to the pIgR initiates a signaling cascade that stimulates transcytosis.

Nat Cell Biol. 2010 Dec;12(12):1143-53. doi: 10.1038/ncb2118. Epub 2010 Oct 31. PMID: 21037565 Cold Spring Harb Perspect Biol. 2017 Sep 1;9(9):a027912. doi: 10.1101/cshperspect.a027912. PMID: 28213463

4. Neil E. Simister and Mostov cloned and sequenced the Neonatal Fc Receptor (FcRn), the receptor responsible for transcytosis of IgG and for prolonging the half-life of IgG and serum albumin in the circulation.

https://en.wikipedia.org/wiki/Neonatal_Fc_receptor Nature. 1989 Jan 12;337(6203):184-7. doi: 10.1038/337184a0. PMID: 2911353 Nature. 1989 Jan 12;337(6203):118-9. doi: 10.1038/337118a0. PMID: 2911346 Nature Rev Immunol. 2007 Sep;7(9):715-25. doi: 10.1038/nri2155.

5. Mostov and colleagues studied how polarized epithelial cells form three-dimensional structures with lumens and tubules.

Dev Cell. 2014 Oct 27;31(2):171-87. doi: 10.1016/j.devcel.2014.08.027. Epub 2014 Oct 9. PMID: 25307480 https://en.wikipedia.org/wiki/Madin-Darby_Canine_Kidney_cells

They showed that phosphoinsoitol phospholipids are identity determinants for the polarized domains of epithelial cells.

Nat Rev Mol Cell Biol. 2014 Apr;15(4):225-42. doi: 10.1038/nrm3775. PMID: 24651541 Nat Commun. 2018 Nov 28;9(1):5041. doi: 10.1038/s41467-018-07464-8. PMID: 30487552

6. Mostov and colleagues showed how simple rules cause different branching patterns in kidney as compared to other branching tubular organs. Cell Syst. 2019 Sep 25;9(3):221-227. doi: 10.1016/j.cels.2019.08.001. PMID: 31557453

Honors

Honors received by Mostov include:

Rhodes Scholar https://www.nytimes.com/1976/09/30/archives/new-jersey-pages-rhodes-scholars-from-a-playwright-to-a-soldier.html?searchResultPosition=3

Searle Scholar https://www.searlescholars.net/scholarships/all?grouping=year

American Society for Cell Biology ASCB Fellow https://www.ascb.org/grants-awards/fellows/