User:Kneal0627/sandbox

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Multiple Sclerosis
Multiple Sclerosis (MS) is an autoimmune disease characterized by the deterioration of the myelin sheaths which protect neurons. While several treatment options are available, researchers continue to investigate further treatment options as they search for a cure to MS. Vitamin A has recently been suggested to be added to current treatment options. Vitamin A plays a pivotal role in immunological response as well as brain development. Retinoic acid (RA), the metabolite of Vitamin A, is known to associate with nuclear receptor-mediated signaling pathways in the brain. Due to its metabolite RA, Vitamin A also plays a key role in regeneration, cognition, behavior, and plasticity. Due to its various functions, it is speculated that Vitamin A had dual functions but may also provide brain function. Although magnetic resonance imaging (MRI) provides the optimal way to monitor the progression of MS, new developments in position emission tomography (PET) may offer a way to investigate underlying MS pathophysiology, such as demyelination and remyelination. Vitamin A trials could potentially be monitored using PET as well as MRI.

Preliminary Outline
I. Gene Cluster defined
 * a. Creation of gene clusters
 * i. Gene Duplication
 * ii. Tandem arrays vs. Gene Clusters
 * b. Examples

II. Bioinformatics
 * a. Cluster trees
 * b. Maps

III. Research

Possible Figures/Images to Use

 * Here is one possibility. It shows a olfactory receptor gene clusters: http://www.nature.com/nature/journal/v440/n7083/fig_tab/nature04632_F2.html
 * This is a figure displaying the Hox gene clusters among several species. This image is taken from another Wikipedia article about the Hox gene, so it would be suitable to use in this article. It is also a really good example to discuss in the article. https://en.wikipedia.org/wiki/File:Genes_hox.jpg