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=Overview= The family with sequence similarity 43 member A (FAM43A) gene codes for a protein that is conserved in primates, and orthologs have been found in vertebrate and invertebrate species. Three transcripts have been identified, an un-spliced non-coding transcript ad two protein coding isoforms.

Gene
Located on the long arm of Chromosome 3 at 3q29, is comprised of 2,493 bases containing a phosphotyrosine interaction domain, putative phosphoinositide binding site and putative peptide binding sites. Expression at high levels has been recorded in the brain (22), tumor tissue (20), lung (13), spleen (12), pancreas (11), and other tissues. The similar gene in Caenorhabditis elegans XM208, is expressed at a high level (92%) in the embryo and not expressed in the adult; maps to the X-chromosome and the in vivo function is unknown. Global alignment of FAM43A genes of H. sapiens, G. gallus, and C. elegans can be seen below, with G. gallus sharing 72.4% similarity, and C. elegans 35.6%.

Introduction
The FAM43A gene has been identified in cDNA screening as a possible cancer development and progression candidate gene. Unpublished data from Zhang et al. indicates that FAM43A could possess tumor suppressor function however the direct interaction is unknown. As well as playing a role in cancer development, FAM43A has been identified as a possible autism spectrum disorder (ASD) candidate gene, with mutations within the upstream SNP rs789859 correlating with the presentation of ASD and learning disorder; suggesting that this SNP is the promoter region for the downstream FAM43A gene. The 2014 study completed by Baron-Cohen et al. involved the screening of 906 K SNPs within the genome to identify possible candidate genes, with FAM43A being the closest gene to the polymorphism.

Variation
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