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Electrophysiological recordings from brain slices are a direct way to probe neural function, detect pathological functional abnormalities and explore the sensitivity of spontaneous and evoked electrical signal transmissions to drugs.

The recordings are a valuable tool in the study of synaptic plasticity, which is thought to underlie learning, memory and brain pathologies. Up-regulation or down-regulation of synaptic transmissions give insight on cellular and network mechanisms of numerous central nervous system diseases, including Alzheimer’s disease, autism and ataxia.

Neuronal electrophysiology (ephys) is the study of the electrical properties of biological cells and tissues in the nervous system. Changes in these properties allow the nervous system to perform its important functions. These are not only responsible for keeping us alive, but also responsible for allowing us to achieve higher levels of consciousness.

Multi-electrode arrays (MEAs) or microelectrode arrays are devices that contain multiple plates or shanks through which neural signals are obtained or delivered, essentially serving as neural interfaces that connect neurons to electronic circuitry. Multi-electrode arrays (MEAs) are ideal for neural studies, as they are easily multiplexed, allowing for multiple, concurrent experiments. The variety of MEA biochips allows one to customize the electrophysiological recordings and gather data from single neurons to large groups of cells.

https://www.scientifica.uk.com/neurowire/neuronal-electrophysiology-the-study-of-excitable-cells

https://www.criver.com/products-services/discovery-services/vivo-pharmacology/neuroscience-translational-tools/electrophysiology/brain-slice-electrophysiology?region=3601

https://www.researchgate.net/topic/Multielectrode-Arrays

Neuronal electrophysiology

In reference to the brain, there are two main ways of recording neuronal evidence from neuronal electrophysiology. Due to membrane depolarization and a consistently positive charge, intracellular recordings are considered to have a millivolt amplitude. Extracellular recordings waver in electrical potential and the amplitude is in microvolt. These cellular recordings of electrical neuronal activity can be measured by either a magnetoencephalography or electroencephalogram.

Biological cells and tissues in the nervous system can be studied by their electrical properties using neuronal electrophysiology. Our nervous systems perform their functions as a result of the changes in those cells and tissues. These changes also allow us to expand our consciousnesses as well as keeping us alive. Electrical signal transmissions' response to drugs can be evoked by electrophysiological recordings from brain slices. These recordings can also explore, detect and probe different sensitivities, neural functions and abnormalities in the brain. Synaptic plasticity, changes at synapses, can be studied using electrophysiological recordings. Brain pathologies, memory and learning are a few examples of what can be affected by synaptic plasticity. Alzheimer's disease, autism and ataxia are some examples of central nervous system diseases that can be further explored by the regulation of synaptic transmissions. Multi-electrode arrays are multi-purpose and are the main choice for neural research. Multi-electrode arrays, also called microelectrodes, are devices that transmit neural signals. These devices can have multiple experiments performed on them because they are multiplexed. Electrophysiological recordings, with MEA help, can not only gather data from groups of cells, but also from single neurons.