User:Kshadman/KDM1A

Interactions (My addition to existing sentences )
There is also evidence for the role of KDM1A interactions with nuclear GSK3β in promoting the progression of certain cancers. High levels of nuclear GSK3β were found to promote the binding of KDM1A to the deubiquitinase, USP22, which prevent the breakdown of KDM1A and cause it to accumulate in higher levels. The accumulation of KDM1A has been correlated with tumor progression in certain cancers, including glioblastoma, leukemia, and osteosarcoma.

Clinical significance (My addition to existing sentences)
KDM1A is also thought to play a role in cancer, as poorer outcomes can be correlated with higher expression of this gene (Not my sentence--present in the previous version of the article). Therefore, the inhibition of KDM1A may be a possible treatment for cancer (Not my sentence--present in the previous version of the article). KDM1A tends to be overexpressed in the tumor cells of certain cancers such as bladder, lung, and colorectal cancers. The specificity of KDM1A overexpression in these cancers creates the potential for targeted molecular therapy treatments, through the use of KDM1A specific siRNAs