User:Kwona1/sandbox

Questions to consider evaluating article
This is my topic: Dopamine receptor

Choose at least 1 question relevant to the article you're evaluating and leave your evaluation on the article's Talk page. Be sure to sign your feedback with four tildes — ~.


 * What kinds of conversations, if any, are going on behind the scenes about how to represent this topic?
 * talk about the headings/ layouts
 * the awkward word choice
 * DRD4
 * plagiarism
 * How is the article rated? Is it a part of any WikiProjects?
 * dopamine receptors
 * rates class B
 * part of molecular and cell biology, neuroscience, and pharmacology
 * How does the way Wikipedia discusses this topic differ from the way we've talked about it in class?
 * dopamine talks about the different ways it affects us
 * talks about classes of dopamine
 * interesting that there are other regulators of dopamine, which is expected because one does not produce one


 * Check a few citations. Do the links work? Does the source support the claims in the article?
 * a few sources do not support the claims in the article
 * Is each fact referenced with an appropriate, reliable reference? Where does the information come from? Are these neutral sources? If biased, is that bias noted?
 * neutral voice
 * journals


 * Is the article neutral? Are there any claims that appear heavily biased toward a particular position?
 * neutral
 * Are there viewpoints that are overrepresented, or underrepresented?
 * does not talk about the benefits or harms


 * Is everything in the article relevant to the article topic? Is there anything that distracted you?
 * no
 * Is any information out of date? Is anything missing that could be added?
 * more information in general
 * DRD4
 * classes of dopamine D1, etc.
 * What else could be improved?
 * a picture of the pathway
 * need to add citations
 * add to the talk page to see if they are good citations
 * sources about D1 and DRD4
 * D1 and D2 in rats
 * add to section on addictive drugs
 * D1 and D2 involvement in pain
 * under role in central nervous system
 * histamine and D1 and D2
 * may insert another section with the involvement of histamine
 * DRD2 and DRD4 in chickens pituitary prolactin formation
 * may add another section of pituitary prolactin formation - under central nervous system
 * Dopamine D2L receptor-interacting proteins regulate dopaminergic signaling
 * Schematic diagram showing D2 receptor long isoform (D2LR) signaling events
 * a helpful diagram
 * The dopamine D4 receptor: biochemical and signalling properties
 * "the D4 receptor is able to undergo N-linked glycosylation on a single conserved site (Asn 3), and that this glycosylation is not involved in ligand binding or receptor trafficking to the plasma membrane [27, 28, 29] "
 * "Schematic illustration of the D4.2 receptor and its interacting proteins. "
 * "Further downstream, activation of the D4 receptor has been demonstrated to activate NFκB, an important transcription factor that plays a role in inflammation"
 * "Dopamine D4 receptors have been reported to influence intracellular calcium levels through a variety of different mechanisms, depending on the cell type"
 * Ca2+, cAMP - all similar to our in class Quiz #1
 * "D2-like receptors can influence different types of potassium channel."
 * "D4 receptors can also induce arachidonic acid release, probably via G-proteins and PKC activation [28, 57, 58] and affect the activity of Na+/H+ exchangers, which regulate intracellular pH, extracellular acidification and cell volume [59, 60]."
 * "Very recently it was shown that intracellular PDGFβ receptors can also be transactivated by D4 receptors

For Peer Review (Only citations from 6-11)

 * http://rstb.royalsocietypublishing.org/content/363/1507/3181
 * I will create a new section titled "Pathological gambling" in the disease section (underneath addictive drugs) of the wikipedia page:
 * Pathological gambling is classified as a mental health disorder that has been linked to obsessive-compulsive spectrum disorder and behavioral addiction. Dopamine has been associated with reward and reinforcement in relation to behaviors and drug addiction . The role between dopamine and pathological gambling may be a link between cerebrospinal fluid measures of dopamine and dopamine metabolites in pathological gambling . Molecular genetic study shows that pathological gambling is associated with the TaqA1 allele of the Dopamine Receptor D2 (DRD2) dopamine receptor. Furthermore, TaqA1 allele is associated with other reward and reinforcement disorders, such as substance abuse and other psychiatric disorders. Reviews of these studies suggest that pathological gambling and dopamine are linked; however, the studies that succeed in controlling for race or ethnicity, and obtain DSM-IV diagnoses do not show a relationship between TaqA1 allelic frequencies and the diagnostic of pathological gambling.
 * I will create another section in the disease section titled, "Parkinson's disease" under schizophrenia:
 * Parkinson's disease is associated with the degeneration of dopamine and other neurodegenerative events . Parkinson's disease patients are treated with drugs help dopamine function and neurotransmission . Research shows that Parkinson's disease is linked to the class of dopamine agonists instead of specific agents. Reviews touch upon the need to control and regulate dopamine doses for Parkinson's patients who may be predisposed to abusing drugs or not being able to tolerate high doses.
 * https://link.springer.com/article/10.1007/s00018-010-0293-y
 * I will add a sentence to the dopamine receptors introduction:
 * Dopamine receptors activate different effectors through not only G-protein coupling, but also signaling through different protein (dopamine receptor-interacting proteins) interactions.
 * Dopamine receptors activate different effectors through not only G-protein coupling, but also signaling through different protein (dopamine receptor-interacting proteins) interactions.

Responding to Peer Review

 * Noa peer-reviewed my article and suggested that I change my primary articles to review articles. I had struggled with knowing what to cite and how to do it and her comment clarified my misunderstanding. I modified my citations to fit the citations of the reviews that I had pulled from instead of the primary articles that were cited within my reviews. Noa was not the only one concerned, but someone on the talk page of the Dopamine Receptor on Wikipedia pointed out that I had been using primary literature articles. I took into consideration both of their concerns and modified my citations to show that I did, in fact, pull from reviews. Furthermore, Noa found a sentence with grammatical errors in it that I fixed for publishing onto the Dopamine Receptor page. Additionally, I removed odd sentences and "also's" from my additions. Also, I wrote only findings that the review articles state instead of forming my on research that wikipedia does not approve of.