User:Kwoods8/sandbox

Paragraph on intended changes

I want to add content on G-protein coupled receptors in the section on transmembrane receptors and their transmission of a signal because they are a major and important group of these receptors and there is not any information on them in this article. Since I will be adding a section, this follows 4.1 on the Wikiedu rubric, and I believe I accomplished the goal of adding a comprehensive section that does not duplicate other sections as there is no previous information about G-protein coupled receptors. I will also add references for this new information which follows section 3 of the Wikiedu rubric. Every statement is associated with a supporting reference, the sources are the best available and are appropriate for the discipline. Additionally the references can be used to support other material in the article and supplement the citations that are not as strong.

Citation 1- Hormones and the Endocrine System discusses the different types of hormone receptors, the majority of which are G-protein coupled receptors or nuclear receptors. It discusses the exchange of GDP for GTP and the cellular targets.

Citation 2- Principles of Endocrinology and Hormone Action discusses hormone receptors and signal transduction processes. It includes information on all types of hormone receptors. Specifically the information cited is about GPCRs and the signalling mechanism.

Citation 3- Molecular Endocrinology additionally discusses hormones, their receptors and their transduction processes. It specifically discusses the ligand binding interaction and the GDP/GTP exchange.

Citation 4- Molecular Biology of Steroid and Nuclear Hormone Receptors does not discuss GPCRs but it does provide a lot of important information on steroid and nuclear hormone receptors, which can support the already existing information/citations in the article.

Added Content to Hormone Receptor

G-protein-coupled membrane receptors(GPCR) are a major class of transmembrane receptors. The features of G proteins include GDP/GTP binding, GTP hydrolysis and guanosine nucleotide exchange. When a ligand binds to a GPCR the receptor changes conformation, which makes the intracellular loops between the different membrane domains of the receptor interact with G proteins. This interaction causes the exchange of GDP for GTP, which triggers structural changes within the alpha subunit of the G protein. The changes interrupts the interaction of the alpha subunit with the beta–gamma complex and which results in a single alpha subunit with GTP bound and a beta–gamma dimer. The GTP–alpha monomer interacts with a variety of cellular targets. The beta–gamma dimer also can stimulate enzymes within the cells for example, adenylate cyclase but it does not have as many targets as the GTP–alpha complex.

Citations:

Hormones and the Endocrine System pp 247-259 Hormone Receptors

Authors: Bernhard KleineWinfried G. Rossmanith

Principles of Endocrinology and Hormone Action

Molecular Endocrinology

Molecular Biology of Steroid and Nuclear Hormone Receptors

Article Selection: Hormone Receptor (chosen article)


 * Content
 * The content is very general
 * Some parts are out of place ie. breast cancer part in the intro
 * I think the sections can be organized better
 * More detail on binding and signal transduction
 * Maybe explanation of specific hormone receptors
 * Tone
 * Article appears to have a neutral tone
 * Sources
 * Missing sources in some cases
 * Can probably use more reputable sources
 * Talk
 * There is not a lot of discussion. Someone added a lot of information recently but it does not look like it has been edited
 * This article is within the scope of the WikiProject Molecular and Cell Biology. T
 * This article has been rated as Stub-Class on the project's quality scale.
 * This article has been rated as High-importance on the project's importance scale.