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The 2021–22 Arizona Wildcats women's basketball team represented University of Arizona during the 2021–22 NCAA Division I women's basketball season. The Wildcats, led by sixth-year head coach Adia Barnes. This will be the Wildcats' 48th season at the on-campus McKale Center in Tucson, Arizona and 43rd season as a member of the Pac-12 Conference.

Previous season
The Wildcats finished the season second behind Stanford in the Pacific-12 conference with a 13–4 record. They advanced to the semifinals of the 2021 Pac-12 Women's Tournament where they lost to no. 9 ranked UCLA and As a no. 3 seed in the NCAA Tournament where they defeated Stony Brook and BYU in the first and second rounds, no. 4 ranked Texas A&M in the Sweet Sixteen, they won their region with a win over no. 12 ranked Indiana in the first-ever Elite Eight, knocked off no. 1 ranked UConn in the first-ever Final Four. Arizona reached the first-ever National Championship game, losing to no. 2 ranked Stanford (in a rematch from earlier this season) 54–53 and finishing the season with a 21–6 record.