User:Laurenfasth/sandbox

I plan to contribute information on the ADH mutation on the Drosophila melanogaster Wikipedia page. This information will most likely fit under the "genome" tab already present in the article. In particular, I would like to address the impact an ADH mutation has on alcohol tolerance. Below are a list of potential sources for this project:

Alcohol dehydrogenase activities and ethanol tolerance in Anastrepha (Diptera, Tephritidae) fruit-fly species and their hybrids

The Influence of Adh Function on Ethanol Preference and Tolerance in Adult Drosophila melanogaster

The Genetics of Behavioral Alcohol Responses in Drosophila

Alpha-ketoglutarate reduces ethanol toxicity in Drosophila melanogaster by enhancing alcohol dehydrogenase activity and antioxidant capacity


 * Research has shown that the antioxidant alpha-ketoglutarate may be beneficial in reducing the oxidative stress produced by alcohol consumption. A 2016 study concluded that food supplementation with 10-mM alpha-ketoglutarate decreased Drosophila alcohol sensitivity over time.