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Bromperidol (marketed as Bromodol, Impromen) is a drug which is a butyrophenone derivative. It is a potent and long-acting neuroleptic, used as an antipsychotic in the treatment of schizophrenia. It was discovered at Janssen Pharmaceutica in 1966. Like other typical antipsychotics, bromperidol is a dopamine D2 receptor antagonist. Bromperidol shares many pharmacokinetic and pharmacodynamic features with haloperidol, another butyrophenone derivative. Both have a much higher affinity for D2 receptors than for serotonin 5-HT2A receptors.

Treatment
Bromperidol has been demonstrated to improve symptoms of schizophrenia including positive symptoms, excitement, anxiety, and depression. However, like most other typical antipsychotics, it does not treat the negative or cognitive symptoms of schizophrenia.

Side Effects
Clinical trials have shown bromperidol can cause extrapyramidal symptoms, including dystonia. The risk of developing dystonia may be related to age, as younger patients were more likely to develop dystonia in one study.