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Green Coffee extract is used as a weight-loss supplement and as an ingredient in other weight-loss products. Its efficacy and mechanism of action have been the subject of controversy.

History
In April and September 2012, The Dr. Oz Show featured green coffee extract, and conducted its own placebo-controlled study as to its efficacy. Dr. Oz specifically recommended either Svetol or GCA as the green coffee extract brands to assist with weight-loss goals. As of 2013, Svetol has increasingly been cited as one of the two brands of green coffee extract that is standardized to contain at least 45% chlorogenic acid, and as the brand of choice for green coffee extract supplementation.

Clinical studies and mechanism of action
In a study published in 2006 in Phytothérapie, a randomized, placebo-controlled clinical trial used a group of 50 overweight volunteers to test Svetol over the course of 60 days. Subjects receiving Svetol showed significant decrease of weight, body mass index, and fat mass. In a 2007 report published in AgroFOOD Industry Hi-Tech, studies carried out on Svetol's efficacy and the mechanism of action were reviewed, including two clinical trials and an in vitro study. The report concluded that "Svetol has demonstrated its validity and could be used to aid the recommended diet in a useful and positive manner." The report also concluded that Svetol works as a fat burner to reduce body mass index and increase the lean mass to fat mass ratio via two mechanisms of action: by decreasing intestinal absorption of glucose and also by inhibiting glucose-6-phosphatase in the liver. A study published in 2007 in the Journal of International Medical Research detailed two randomized clinical studies which measured the effects on glucose absorption and body mass of a coffee product whose active component was Svetol. The study concluded that Svetol has a significant effect on the absorption and utilization of dietary glucose, and if used for an extended time can result in reduced body mass and body fat.

A 2010 in vitro study detailed in the Journal of Agricultural and Food Chemistry showed that Svetol significantly inhibited glucose 6-phosphate hydrolysis in intact human liver microsomes in a competitive manner, and that this inhibition by Svetol contributes to its antidiabetic, glucose-lowering effects by reducing hepatic glucose production. An overview of randomized clinical trials published in 2011 in Gastroenterology Research and Practice reiterated that intake of Svetol can promote weight loss. In a 2012 study using mice, published in Nutritional Neuroscience, Svetol's effect on insulin resistance and brain energy metabolism was investigated. Svetol significantly attenuated the development of high-fat diet-induced deficits in glucose-tolerance response; it also improved brain mitochondrial energy metabolism, and modulated a number of genes in the brain that are implicated in cellular energy metabolism. And a 2013 study published in Phytotherapy Research determined that longterm Svetol use has a lipolytic activity unrelated to possible trace amounts of caffeine; the study concluded that the release of free fatty acids from adipose tissue from longterm Svetol use is due to Svetol's chlorogenic acid action.