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Ingrid Grummt (* 26. November 1943 ) is a german molecular and cellular biologist. She holds a Helmoholtz professorship at the German Cancer Research Center (Deutschen Krebsforschungszentrum, DFKZ) in Heidelberg, Germany.

Education
Beginning in 1962, Ingrid Grummt studied biology at the Humboldt University of Berlin. She gained her doctoral degree in natural sciences (Dr. rer. nat.) in 1970. She subsequently completed post-docorates at both the German Academy of Sciences in Berlin and the Max-Planck-Insitute for Biology in Munich. In 1977, she completed her habilitation, the highest academic degree in Germany, at the Ludwig Maximillian University of Munich.

Career
From 1980 to 1984, Ingrid Grummt led a research group at the Universit of Würzburg Institute for Biochemistry. In 1985, she became a professor of microbiology in Würzburg until 1989, when she became the manageing director of the German Cancer Research Center (DFKZ) in Heidelberg. She served on the Board of Trustees of the DFKZ from 1992 to 2005.

Her research focuses on the gene regulation of mammalian cells, specifically the mechanisms by which environmental signals impact gene transcription.

Sie befasst sich mit der Genregulation in Säugerzellen, insbesondere dem Mechanismus, wie äußere Umweltsignale die Transkription des Genoms der Zelle ändern. Dazu gehören auch fehlgeleitete Genexpressions-Prozesse wie bei Krebs oder anderen Erkrankungen.

Additionally, her research deals with epigenetic mechanisms which control gene expression by changing the structure of chromatin, the DNA-protein complex which packages and protects DNA in the nucleus. Chromatin changes can prevent or enable specific sections of the genome to be transcribed. Grummt's research demonstrated that non-coding RNA (ncRNA) plays a role in epigenetic gene regulation through DNA methylation and resulting suppression of genes. The resulting methylation patterns have been shown to differ between healthy and cancerous cells, which Grummt continued to investigate.

She also discovered a protein complex (NoRC), which represses the transcription of ribosomal RNAs (rRNAs) by packing the coding regions of the chromosomes more tightly. The decrease in rRNAs is shown to play an important role in aging and genetic disorders

Awards
Ingrid Grummt was awarded the Gottfried Wilhelm Leibniz Prize in 1990, and the Schleiden Medal of Leopoldina in 2013. In 2008, she received an ERC Advanced Grandt. She is a member of Leopoldina

Leopoldina: " the world’s oldest continuously existing academy of natural sciences, founded in 1652 in Schweinfurt, a city in the German state of Bavaria."

1990 erhielt sie den Gottfried-Wilhelm-Leibniz-Preis und 2013 die Schleiden-Medaille der Leopoldina. 2008 erhielt sie einen ERC Advanced Grant. Sie ist Mitglied der Leopoldina und der Academia Europaea (1998). Seit 1985 ist sie Mitglied der European Molecular Biology Organisation (EMBO) und 2002 bis 2007 war sie in dessen Rat. 2010 erhielt sie den Women in Science Award von FEBS und EMBO. 2012 wurde sie mit dem Prix International de l’INSERM ausgezeichnet.

Weblinks

 * Homepage DKFZ
 * Curriculum Vitae, Leopoldina, pdf
 * Mitteilung der DKFZ zur Schleiden-Medaille für Grummt