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Arnon Rosenthal, Ph.D. is an Israeli-American neuroscientist, inventor and a biotechnology entrepreneur. He is an author on 85 U.S and 393 international patents and applications and 110 peer reviewed, scientific publications.

Dr. Rosenthal is an inventor and developer of the pain medicine Tanezumab, the migraine medicine Fremanezumab, the Alzehimer’s drug Ponezumab and the target for the basal cell carcinoma medicine Vismodegib. Dr. Rosenthal founded the biotechnology companies Rinat Neuroscience Corporation in 2001 (acquired by Pfizer in 2006 ), Annexon, which develops anti complement medicines for auto immune neuropathies and degenerative eye diseases, in 2011 and Alector, which develops innate immune (immuno-neurology) drugs for dementia and neurodegeneration, in 2013.

Dr. Rosenthal received his PhD from the Hebrew University Jerusalem, Israel, and then conducted a postdoctoral fellowship at Genentech, Inc. He was part of the core scientific team and member or the research review committee at Genetech for 16 years.

He is a member of the scientific advisory boards of the Simons Foundation Autism Research Initiative, was a member of the scientific advisory boards of the pharmaceutical company UCB and the Myelin Repair Foundation and was a visiting professor of the Department of Anatomy at the University of California San Francisco.

Selected scientific Publications


 * 1) Henderson, C., Camu, W., Mettling, C., Poulsen, C., Karihaloo, M., Rullamas, J., Evans, T., McMahon, B.S., Armanini, P.M., Berkemeier, L., Phillips, S.H. and Rosenthal, A. (1993) Brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-5 promote motoneuron survival and are present in embryonic limb bud.  Nature 363, 266-270.
 * 2) Henderson, C.E., Phillips, H.S., Pollock, R.A., Davies, A.M., Lemeulle, C., Armanini, M., Simmons, L., Moffet, B., Vandlen, R.A., Koliatsos, V.E. and Rosenthal, A. (1994) GDNF:  A potent survival factor for motoneurons present in peripheral nerve and muscle.  Science 266, 1062-1064.
 * 3) Hynes, M., Poulsen, K., Tessier-Lavigne, M. and Rosenthal, A. (1995) Control of neuronal diversity by the floor plate: contact-mediated induction of midbrain dopaminergic neurons.  Cell 80, 95-101.
 * 4) Hynes, M., Porter, J.A., Chiang, C., Chang, D., Tessier-Lavigne, M., Beachy, P.A. and Rosenthal, A. (1995) Induction of midbrain dopaminergic neurons by sonic hedgehog.  Neuron 15, 35-44.
 * 5) Moore, M.W., Klein, R.D., Fariñas, I., Sauer, H., Armanini, M., Phillips, H., Reichardt, L.F., Ryan, A.M., Carver-Moore, K., and Rosenthal, A. (1996) Renal and neuronal abnormalities in mice lacking GDNF.  Nature 382, 76-79.
 * 6) Treanor, J., Goodman, L., de Sauvage, F., Stone, D., Poulsen, K., Beck, K., Gray, C., Armanini, M., Pollock, R.A., Hefti, F., Phillips, H., Goddard, A., Davies, A., Asai, N., Takahashi, M., Vandlen, R., Henderson, C., and Rosenthal, A. (1996) Characterization of a multicomponent receptor for GDNF.  Nature 382, 80-83.
 * 7) Stone, D.M., Hynes, M., Armanini, M., Swanson, T.A., Gu, Q., Johnson, R.L., Scott, M.P., Pennica, D., Goddard, A., Phillips, H., Noll, M., Hooper, J.E., deSauvage, F., and Rosenthal, A. (1996) The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384, 129-134.
 * 8) Klein, R.D., Sherman, D., Ho, W.-H., Stone, D., Bennett, G.L., Moffat, B., Vandlen, R., Simmons, L., Gu, Q., Hongo, J.-A., Devaux, B., Poulsen, K., Armanini, M., Nozaki, C., Asai, N., Goddard, A., Phillips, H., Henderson, C.E., Takahashi, M., and Rosenthal, A. (1997) A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor.  Nature 387, 717-721.
 * 9) Cacalano, G., Fariñas, I., Wang, L.-C., Hagler, K., Forgie, A., Moore, M., Armanini, M., Phillips, H., Ryan, A.M., Reichardt, L.F., Hynes, M., Davies, A., and Rosenthal, A. (1998) GFR1 is an essential receptor component for GDNF in the developing nervous system and kidney.  Neuron 21, 53-62.
 * Ye, W., Shimamura, K., Rubenstein, J.L.R., Hynes, M.A., and Rosenthal, A. (1998) FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell 93, 755-766.
 * 1) Cacalano, G., Fariñas, I., Wang, L.-C., Hagler, K., Forgie, A., Moore, M., Armanini, M., Phillips, H., Ryan, A.M., Reichardt, L.F., Hynes, M., Davies, A., and Rosenthal, A. (1998) GFR1 is an essential receptor component for GDNF in the developing nervous system and kidney.  Neuron 21, 53-62.
 * 2) Guo, S., Brush, J., Teraoka, H., Goddard, A., Wilson, S., Mullins, C.M., and Rosenthal, A. (1999) Specification of Noradrenergic Neurons in the Zebrafish Hindbrain Requires BMP and FGF8 Signals and is Executed by the Homeodomain Protein Soulless/Zphox2a. Neuron 24, 555-566.
 * 3) Guo, S., Yamaguchi, Y., Schilbach, S., Wada, T., Lee, J., Goddard, A., French, D., Handa, H., and Rosenthal, A. (2000) A regulator of transcriptional elongation controls vertebrate neuronal development.  Nature 408, 366-369.
 * 4) Abeliovich, A., Schmitz, Y., Fariñas, I., Choi-Lundberg, D., Ho, W-H., Castillo, P.E., Shinsky, N., Garcia Verdugo, J.M., Armanini, M., Ryan, A., Hynes, M., Phillips, H., Sulzer, D., and Rosenthal, A. (2000) Mice lacking -synuclein display functional deficits in the nigrostriatal dopamine system.  Neuron 25, 235-252.
 * Ye, W., Bouchard, M., Stone, D., Liu, X., Vella, F., Lee, J., Nakamura, H., Ang, S. L., Busslinger, M., and Rosenthal, A. (2001) Distinct regulators control the expression of the mid-hindbrain organizer signal FGF8. Nature Neuroscience 4, 1175-1181.
 * 1) Levkowitz, G., Zeller, J., Sirotkin, H.I., Schilbach, S., Hashimoto, H., Hibi, M., Talbot, W.S., and Rosenthal, A. (2003) Zinc finger protein too few controls the development of monoaminergic neurons. Nature Neuroscience 6, 28-3.
 * 2) Rosenthal, A., Wright, S., Cedar, H., Flavell, R. and Grosveld, F. (1984) Regulated expression of an introduced MHC H-2Kbm1 gene in murine embryonal carcinoma cells. Nature 310, 415-418.
 * 3) Rosenthal, A., Wright, S., Quade, K., Gallimore, P., Cedar, H. and Grosveld, F. (1985) Increased MHC H-2K gene transcription in cultured mouse embryo cells after adenovirus infection. Nature 315, 579-581.
 * 4) Rosenthal, A., Lindquist, P.B., Bringman, T.S., Goeddel, D.V. and Derynck, R. (1986) Expression in rat fibroblasts of a human transforming growth factor- cDNA results in transformation. Cell 46, 301-309
 * 1) Cacalano, G., Fariñas, I., Wang, L.-C., Hagler, K., Forgie, A., Moore, M., Armanini, M., Phillips, H., Ryan, A.M., Reichardt, L.F., Hynes, M., Davies, A., and Rosenthal, A. (1998) GFR1 is an essential receptor component for GDNF in the developing nervous system and kidney.  Neuron 21, 53-62.
 * 2) Guo, S., Brush, J., Teraoka, H., Goddard, A., Wilson, S., Mullins, C.M., and Rosenthal, A. (1999) Specification of Noradrenergic Neurons in the Zebrafish Hindbrain Requires BMP and FGF8 Signals and is Executed by the Homeodomain Protein Soulless/Zphox2a. Neuron 24, 555-566.
 * 3) Guo, S., Yamaguchi, Y., Schilbach, S., Wada, T., Lee, J., Goddard, A., French, D., Handa, H., and Rosenthal, A. (2000) A regulator of transcriptional elongation controls vertebrate neuronal development.  Nature 408, 366-369.
 * 4) Abeliovich, A., Schmitz, Y., Fariñas, I., Choi-Lundberg, D., Ho, W-H., Castillo, P.E., Shinsky, N., Garcia Verdugo, J.M., Armanini, M., Ryan, A., Hynes, M., Phillips, H., Sulzer, D., and Rosenthal, A. (2000) Mice lacking -synuclein display functional deficits in the nigrostriatal dopamine system.  Neuron 25, 235-252.
 * Ye, W., Bouchard, M., Stone, D., Liu, X., Vella, F., Lee, J., Nakamura, H., Ang, S. L., Busslinger, M., and Rosenthal, A. (2001) Distinct regulators control the expression of the mid-hindbrain organizer signal FGF8. Nature Neuroscience 4, 1175-1181.
 * 1) Levkowitz, G., Zeller, J., Sirotkin, H.I., Schilbach, S., Hashimoto, H., Hibi, M., Talbot, W.S., and Rosenthal, A. (2003) Zinc finger protein too few controls the development of monoaminergic neurons. Nature Neuroscience 6, 28-3.
 * 2) Rosenthal, A., Wright, S., Cedar, H., Flavell, R. and Grosveld, F. (1984) Regulated expression of an introduced MHC H-2Kbm1 gene in murine embryonal carcinoma cells. Nature 310, 415-418.
 * 3) Rosenthal, A., Wright, S., Quade, K., Gallimore, P., Cedar, H. and Grosveld, F. (1985) Increased MHC H-2K gene transcription in cultured mouse embryo cells after adenovirus infection. Nature 315, 579-581.
 * 4) Rosenthal, A., Lindquist, P.B., Bringman, T.S., Goeddel, D.V. and Derynck, R. (1986) Expression in rat fibroblasts of a human transforming growth factor- cDNA results in transformation. Cell 46, 301-309
 * Ye, W., Bouchard, M., Stone, D., Liu, X., Vella, F., Lee, J., Nakamura, H., Ang, S. L., Busslinger, M., and Rosenthal, A. (2001) Distinct regulators control the expression of the mid-hindbrain organizer signal FGF8. Nature Neuroscience 4, 1175-1181.
 * 1) Levkowitz, G., Zeller, J., Sirotkin, H.I., Schilbach, S., Hashimoto, H., Hibi, M., Talbot, W.S., and Rosenthal, A. (2003) Zinc finger protein too few controls the development of monoaminergic neurons. Nature Neuroscience 6, 28-3.
 * 2) Rosenthal, A., Wright, S., Cedar, H., Flavell, R. and Grosveld, F. (1984) Regulated expression of an introduced MHC H-2Kbm1 gene in murine embryonal carcinoma cells. Nature 310, 415-418.
 * 3) Rosenthal, A., Wright, S., Quade, K., Gallimore, P., Cedar, H. and Grosveld, F. (1985) Increased MHC H-2K gene transcription in cultured mouse embryo cells after adenovirus infection. Nature 315, 579-581.
 * 4) Rosenthal, A., Lindquist, P.B., Bringman, T.S., Goeddel, D.V. and Derynck, R. (1986) Expression in rat fibroblasts of a human transforming growth factor- cDNA results in transformation. Cell 46, 301-309
 * 1) Rosenthal, A., Wright, S., Quade, K., Gallimore, P., Cedar, H. and Grosveld, F. (1985) Increased MHC H-2K gene transcription in cultured mouse embryo cells after adenovirus infection. Nature 315, 579-581.
 * 2) Rosenthal, A., Lindquist, P.B., Bringman, T.S., Goeddel, D.V. and Derynck, R. (1986) Expression in rat fibroblasts of a human transforming growth factor- cDNA results in transformation. Cell 46, 301-309
 * 1) Rosenthal, A., Lindquist, P.B., Bringman, T.S., Goeddel, D.V. and Derynck, R. (1986) Expression in rat fibroblasts of a human transforming growth factor- cDNA results in transformation. Cell 46, 301-309
 * 1) Rosenthal, A., Lindquist, P.B., Bringman, T.S., Goeddel, D.V. and Derynck, R. (1986) Expression in rat fibroblasts of a human transforming growth factor- cDNA results in transformation. Cell 46, 301-309