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Cilia and flagella associated protein 157 (CFAP157) also known as chromosome 9 open reading frame 117 (c9orf117) is a protein that in humans is encoded by the CFAP157 gene.

CFAP157 gene is "specifically required during spermatogenesis for flagellum morphogenesis and sperm motility and may be required to suppress the formation of supernumerary axonemes and ensure a correct ultrastructure," according to UniProt.

Gene
CFAP157 is located on chromosome 9, 9q34.11 in human from base pair 127,706,988 to base pair 127,716,002. The size of the gene is 9,015 bases, and the orientation is plus strand. The gene holds 9 exons.

mRNA
The most common variant of mRNAs of CFAP157 contains 1,722 base pairs.

Protein
There are 520 amino acids in CFAP157 in human. Two of the most common amino acids are glutamine and leucine, and the protein is quite neutral with the isoelectric point at pH 7.4. The average mass of the protein is estimated to be 60,531.748 Da, and the absorption coefficient is estimated to be 25,440 M-1 cm-1.

CFAP157 is primarily composed of α-helices, and there is no transmembrane helix. The protein structure making program called Phyre is used to create the predicted structure of CFAP157.

Expression
CFAP157 is expressed in many human body tissues such as cervix, lung, testis, and uterus. People who have uterine tumor are likely to have an expression in CFAP157. This gene is expressed in both adults and fetuses.

Homology
There is no known paralog for CFAP157 in human. CFAP157 has numerous orthologs. The following table contains some of orthologs including human, common chimpanzee, rhesus macaque, cattle, dog, mouse, rat, tropical clawed frog, and zebra fish.

Interacting Proteins

 * P14335 (Kunjin virus strain MRM61C)
 * Interacts by two hybrid array
 * TMEM190
 * CCDC135
 * CCDC17
 * C6orf118
 * LRRC71
 * FAM216B
 * C1orf110