User:Leslieg317537/slitproposal

Slit Proposal - 3/15/12 - Rachel Glad, Kylie Hanzlik, Leslie Garza

Slit is a member of a family of genes that secrete glycoproteins. They mainly use ROBO (roundabout) receptors, as well as others such as HS (heparan sulphate) receptors to perform important cellular and developmental functions such as axon and neuronal guidance. Further, recent studies have found more functions of these genes playing an important role in reproductive tissues.

There are three different subtypes of SLIT genes in vertebrates. All three exhibit the same structure: a signal peptide (SS), four repeating leucine rich domains (LRR), six epidural growth factor (EGF) domains, a laminin G domain, and three more EGF domains. Each SLIT gene is located at a different chromosomal location; SLIT 1 at 10q23.3-q24, SLIT 2 at 4p15.2, and SLIT 3 at 5q35.

For our Wikipedia article, we will expand on the function, structure, identifiers, clinical significance, regulation, interaction, history of the discovery of Slit, as well as the differences in subtypes. Our group plans to meet frequently, and assign different subsections for the article. We can all add to our page and edit each others’ entries as well.

We have used the following resources:

http://www.ncbi.nlm.nih.gov/pubmed/22349628

1: Unni DK, Piper M, Moldrich RX, Gobius I, Liu S, Fothergill T, Donahoo AL, Baisden JM, Cooper HM, Richards LJ. Multiple Slits regulate the development of midline glial populations and the corpus callosum. Dev Biol. 2012 Feb 11. [Epub ahead of print].

http://www.ncbi.nlm.nih.gov/pubmed/16709176

1: Hohenester E, Hussain S, Howitt JA. Interaction of the guidance molecule Slit with cellular receptors. Biochem Soc Trans. 2006 Jun;34(Pt 3):418-21. Review. .

http://www.ncbi.nlm.nih.gov/pubmed/18363568

1: Hohenester E. Structural insight into Slit-Robo signalling. Biochem Soc Trans. 2008 Apr;36(Pt 2):251-6. Review. .

http://www.ncbi.nlm.nih.gov/pubmed/20100881

1: Dickinson RE, Duncan WC. The SLIT-ROBO pathway: a regulator of cell function with implications for the reproductive system. Reproduction. 2010 Apr;139(4):697-704. Epub 2010 Jan 25. Review. ;.

http://www.ncbi.nlm.nih.gov/pubmed/18269211

1: Chédotal A. Slits and their receptors. Adv Exp Med Biol. 2007;621:65-80. Review. .

http://www.ncbi.nlm.nih.gov/pubmed/11755787

1: Nguyen-Ba-Charvet KT, Chédotal A. Role of Slit proteins in the vertebrate brain. J Physiol Paris. 2002 Jan-Mar;96(1-2):91-8. Review. .

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2971463/figure/F1/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2971463/?tool=pubmed